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Details for Product No. ABIN394412

Activating Transcription Factor 3 (ATF3) antibody

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Antigen
Synonyms LRFI, LRF-1, LRG-21, atf-3, zgc:55526, ATF3
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN394412
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen ATF3 (AAH06322, 1 a.a. ~ 182 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6B8
Isotype IgG3 kappa
Specificity ATF3 (AAH06322, 1 a.a. ~ 182 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ATF3
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 20576 DA
Gene ID 12406
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Filén, Ylikoski, Tripathi et al.: "Activating transcription factor 3 is a positive regulator of human IFNG gene expression." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 9, pp. 4990-9, 2010 (PubMed).

Nguyen, Johnsen, Knetter et al.: "Differential gene expression downstream of Toll-like receptors (TLRs): role of c-Src and activating transcription factor 3 (ATF3)." in: The Journal of biological chemistry, Vol. 285, Issue 22, pp. 17011-9, 2010 (PubMed).

Koh, Lim, Joe et al.: "AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in HepG2 human hepatocyte cells." in: The FEBS journal, Vol. 277, Issue 10, pp. 2304-17, 2010 (PubMed).

Wu, Nguyen, Dziunycz et al.: "Opposing roles for calcineurin and ATF3 in squamous skin cancer." in: Nature, Vol. 465, Issue 7296, pp. 368-72, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Alternatives for antigen "Activating Transcription Factor 3 (ATF3)", type "Antibodies"
Hosts (40), (14), (5)
Reactivities (57), (24), (22), (13), (13), (13), (3), (1)
Applications (40), (28), (10), (10), (6), (5), (4), (2), (2), (2), (1), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (7), (5), (4), (2), (2), (1), (1), (1), (1), (1)
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