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LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) (AA 1-159) antibody

Details for Product No. ABIN394413, Supplier: Login to see
Antigen
  • Rbtn-2
  • Rbtn2
  • Rhom-2
  • Ttg2
  • RBTN2
  • RBTNL1
  • RHOM2
  • TTG2
  • wu:fc83a08
  • zgc:111930
  • LMO-2
  • lmo2-A
  • xlmo2
  • rhombotin-2
Epitope
AA 1-159
26
17
8
5
3
2
1
1
1
1
Reactivity
Human
95
7
5
3
2
1
1
1
1
1
1
1
1
Host
Mouse
52
44
3
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
2
2
2
2
1
1
1
1
Application
Western Blotting (WB)
76
34
33
28
18
7
7
3
2
1
Supplier
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Immunogen LMO2 (AAH34041, 1 a.a. ~ 159 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6B8
Isotype IgG1 kappa
Specificity LMO2 (AAH34041, 1 a.a. ~ 159 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name LMO2 (LMO2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 18358 DA
Gene ID 12406
Research Area Transcription Factors, Signaling, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) (AA 1-159) antibody (ABIN394413) LMO2 monoclonal antibody (M01), clone 6B8 Western Blot analysis of LMO2 expression in...
Background publications Younes, Beck, Lossos et al.: "Immunoarchitectural patterns in follicular lymphoma: efficacy of HGAL and LMO2 in the detection of the interfollicular and diffuse components." in: The American journal of surgical pathology, Vol. 34, Issue 9, pp. 1266-76, 2010 (PubMed).

Durnick, Law, Maurer et al.: "Expression of LMO2 is associated with t(14;18)/IGH-BCL2 fusion but not BCL6 translocations in diffuse large B-cell lymphoma." in: American journal of clinical pathology, Vol. 134, Issue 2, pp. 278-81, 2010 (PubMed).

Hirose, Inukai, Kikuchi et al.: "Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)." in: Blood, Vol. 116, Issue 6, pp. 962-70, 2010 (PubMed).

Sun, Shen, Yang et al.: "Homo-binding character of LMO2 isoforms and their both synergic and antagonistic functions in regulating hematopoietic-related target genes." in: Journal of biomedical science, Vol. 17, Issue 1, pp. 22, 2010 (PubMed).

Hosgood, Zhang, Shen et al.: "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity." in: Occupational and environmental medicine, Vol. 66, Issue 12, pp. 848-53, 2009 (PubMed).