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FOXA2 antibody (Forkhead Box A2) (Met12)

Details for Product anti-FOXA2 Antibody No. ABIN394415, Supplier: Log in to see
Antigen
  • ax
  • axl
  • fkd1
  • FOXA2
  • FoxA2-A
  • FoxA2a
  • Hnf-3b
  • HNF-3b
  • HNF-3B
  • HNF-3BETA
  • hnf3-beta
  • HNF3-beta
  • Hnf3b
  • HNF3B
  • hnf3b
  • hnf3beta
  • HNF3beta
  • ik:tdsubc_2g8
  • Tcf-3b
  • TCF3B
  • Tcf3b
  • tcf3b
  • tdsubc_2g8
  • wu:fe05g04
  • xbeta-1
  • xFD-3
  • xx:tdsubc_2g8
Epitope
Met12
35
30
21
19
14
14
13
12
9
8
5
3
3
3
2
2
2
2
2
2
2
1
1
Reactivity
Human
177
29
29
5
2
1
1
1
1
1
1
1
1
Host
Mouse
98
64
20
Clonality (Clone)
Monoclonal ()
Conjugate
This FOXA2 antibody is un-conjugated
8
8
8
8
7
7
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
162
113
79
47
33
13
13
11
6
3
1
1
1
1
Supplier
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Immunogen FOXA2 (NP_068556, 363 a.a. ~ 458 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6C12
Isotype IgG1 kappa
Specificity FOXA2 (NP_068556, 363 a.a. ~ 458 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FOXA2 (FOXA2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 48306 DA
Gene ID 12406
NCBI Accession NP_068556
Research Area Transcription Factors, Chromatin, Signaling, Metabolism, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-FOXA2 antibody (Forkhead Box A2) (Met12) (ABIN394415) Immunofluorescence of to FOXA2 on HeLa cell . FOXA2 monoclonal antibody (M12), clone ...
Immunohistochemistry (IHC) image for anti-FOXA2 antibody (Forkhead Box A2) (Met12) (ABIN394415) anti-Forkhead Box A2 (FOXA2) (Met12) antibody (Image 2)
Background publications Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010

Dayoub, Groitl, Dobner, Bosserhoff, Schlitt, Weiss: "Foxa2 (HNF-3beta) regulates expression of hepatotrophic factor ALR in liver cells." in: Biochemical and biophysical research communications, Vol. 395, Issue 4, pp. 465-70, 2010

Banerjee, Meyer, Mazumdar, Ray, Ray: "Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expression." in: Journal of virology, Vol. 84, Issue 12, pp. 5936-46, 2010

Song, Washington, Crawford: "Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer." in: Cancer research, Vol. 70, Issue 5, pp. 2115-25, 2010

Xing, Cohen, Boerwinkle: "A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels." in: American journal of human genetics, Vol. 86, Issue 3, pp. 440-6, 2010