Forkhead Box A2 (FOXA2) (Met12) antibody

Antigen: Forkhead Box A2 (FOXA2)

Synonyms: HNF3B, TCF3B, MGC19807, Hnf3b, Tcf3b, Hnf-3b, Tcf-3b, HNF3beta, HNF3-beta, ax, axl, fkd1, HNF-3B, MGC101552, tdsubc_2g8, wu:fe05g04, ik:tdsubc_2g8, xx:tdsubc_2g8, hnf3b, tcf3b, hnf3beta, hnf3-beta, FOXA2, HNF-3BETA, HNF-3b, xFD-3, FoxA2a, FoxA2-A, xbeta-1

Binding Site: Met12

Clonality: Monoclonal (6C12)

Host: Mouse

Reactivity: Human

Application: ELISA, Immunofluorescence (IF), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN394415

Additional Information

Alternative name: FOXA2

Gene ID: 3170

UniProt: NP_068556

Immunogen: FOXA2 (NP_068556, 363 a.a. ~ 458 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 6C12

Description: Other names: HNF3B, MGC19807, TCF3B forkhead box A2

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: FOXA2 (NP_068556, 363 a.a. ~ 458 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 48306 DA

Comments:

Background: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.

Synonyms: HNF3B, TCF3B, MGC19807, Hnf3b, Tcf3b, Hnf-3b, Tcf-3b, HNF3beta, HNF3-beta, ax, axl, fkd1, HNF-3B, MGC101552, tdsubc_2g8, wu:fe05g04, ik:tdsubc_2g8, xx:tdsubc_2g8, hnf3b, tcf3b, hnf3beta, hnf3-beta, FOXA2, HNF-3BETA, HNF-3b, xFD-3, FoxA2a, FoxA2-A, xbeta-1

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence

Concentration: 0.5 mg/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Transcription Factors, Chromatin, Signaling, Metabolism, Cell Structure

Restrictions: For Research Use only

Images

Immunofluorescence of to FOXA2 ( Cat# AT2087a ) on HeLa cell . FOXA2 monoclonal antibody (M12), clone 6C12 Western Blot analysis of FOXA2 expression in K-562 ( Cat # L009V1 ).

anti-Forkhead Box A2 (FOXA2) (Met12) antibody (Image 2)

Publications

Product: Xing, Cohen, Boerwinkle: "A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels." in: American journal of human genetics, Vol. 86, Issue 3, pp. 440-6, 2010 (PubMed).

Song, Washington, Crawford: "Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer." in: Cancer research, Vol. 70, Issue 5, pp. 2115-25, 2010 (PubMed).

Banerjee, Meyer, Mazumdar et al.: "Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expression." in: Journal of virology, Vol. 84, Issue 12, pp. 5936-46, 2010 (PubMed).

Dayoub, Groitl, Dobner et al.: "Foxa2 (HNF-3beta) regulates expression of hepatotrophic factor ALR in liver cells." in: Biochemical and biophysical research communications, Vol. 395, Issue 4, pp. 465-70, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).