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RBAK antibody (RB-Associated KRAB Zinc Finger) (AA 51-151)

Details for Product anti-RBAK Antibody No. ABIN394427, Supplier: Log in to see
Antigen
  • RGD1562875
  • ZNF769
Epitope
AA 51-151
22
16
2
2
2
2
2
1
1
Reactivity
Human
39
8
2
Host
Mouse
35
4
Clonality (Clone)
Monoclonal ()
Conjugate
This RBAK antibody is un-conjugated
2
2
2
2
2
2
Application
ELISA, Western Blotting (WB)
37
26
2
1
1
Supplier
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Immunogen RBAK (NP_066986, 51 a.a. ~ 151 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6F9
Isotype IgG2a kappa
Specificity RBAK (NP_066986, 51 a.a. ~ 151 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name RBAK (RBAK Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 82995 DA
Gene ID 12406
NCBI Accession NP_066986
Research Area Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-RBAK antibody (RB-Associated KRAB Zinc Finger) (AA 51-151) (ABIN394427) Detection limit for recombinant GST tagged RBAK is approximately 0.03 ng/mL as a capt...
Background publications Ma, Qi, Du et al.: "Identification of candidate genes for human pituitary development by EST analysis." in: BMC genomics, Vol. 10, pp. 109, 2009 (PubMed).

Trynka, Zhernakova, Romanos et al.: "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. ..." in: Gut, Vol. 58, Issue 8, pp. 1078-83, 2009 (PubMed).

Jeske, So, Kelemen et al.: "Examination of chromosome 7p22 candidate genes RBaK, PMS2 and GNA12 in familial hyperaldosteronism type II." in: Clinical and experimental pharmacology & physiology, Vol. 35, Issue 4, pp. 380-5, 2008 (PubMed).

So, Jeske, Gordon et al.: "No evidence for coding region mutations in the retinoblastoma-associated Kruppel-associated box protein gene (RBaK) causing familial hyperaldosteronism type II." in: Clinical endocrinology, Vol. 65, Issue 6, pp. 829-31, 2006 (PubMed).

Kimura, Wakamatsu, Suzuki et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).