RB-Associated KRAB Zinc Finger (RBAK) (AA 51-151) antibody

Details for Product No. ABIN394427
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Antigen
Synonyms RGD1562875, ZNF769
Epitope
AA 51-151
(9), (8), (2), (2), (2), (1)
Reactivity
Human
(25), (10), (1)
Host
Mouse
(23), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(25), (14), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394427
450.00 $
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Immunogen RBAK (NP_066986, 51 a.a. ~ 151 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6F9
Isotype IgG2a kappa
Specificity RBAK (NP_066986, 51 a.a. ~ 151 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name RBAK
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 82995 DA
Gene ID 12406
NCBI Accession NP_066986
Research Area Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-RB-Associated KRAB Zinc Finger (RBAK) (AA 51-151) antibody Detection limit for recombinant GST tagged RBAK is approximately 0.03 ng/mL as a capture antibody.
Background publications Talmud, Drenos, Shah et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

So, Jeske, Gordon et al.: "No evidence for coding region mutations in the retinoblastoma-associated Kruppel-associated box protein gene (RBaK) causing familial hyperaldosteronism type II." in: Clinical endocrinology, Vol. 65, Issue 6, pp. 829-31, 2006 (PubMed).

Jeske, So, Kelemen et al.: "Examination of chromosome 7p22 candidate genes RBaK, PMS2 and GNA12 in familial hyperaldosteronism type II." in: Clinical and experimental pharmacology & physiology, Vol. 35, Issue 4, pp. 380-5, 2008 (PubMed).

Trynka, Zhernakova, Romanos et al.: "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling." in: Gut, Vol. 58, Issue 8, pp. 1078-83, 2009 (PubMed).

Ma, Qi, Du et al.: "Identification of candidate genes for human pituitary development by EST analysis." in: BMC genomics, Vol. 10, pp. 109, 2009 (PubMed).

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