RB-Associated KRAB Zinc Finger (RBAK) (AA 51-151) antibody

Details for Product No. ABIN394427
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Synonyms RGD1562875, ZNF769
AA 51-151
(20), (16), (2), (2), (2), (2), (1), (1)
(37), (9), (2)
(34), (3)
Clonality (Clone)
Monoclonal ()
(2), (2), (2), (2), (2), (2)
ELISA, Western Blotting (WB)
(36), (24), (3), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen RBAK (NP_066986, 51 a.a. ~ 151 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6F9
Isotype IgG2a kappa
Specificity RBAK (NP_066986, 51 a.a. ~ 151 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name RBAK (RBAK Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 82995 DA
Gene ID 12406
NCBI Accession NP_066986
Research Area Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-RB-Associated KRAB Zinc Finger (RBAK) (AA 51-151) antibody (ABIN394427) Detection limit for recombinant GST tagged RBAK is approximately 0.03 ng/mL as a capt...
Background publications Ma, Qi, Du et al.: "Identification of candidate genes for human pituitary development by EST analysis." in: BMC genomics, Vol. 10, pp. 109, 2009 (PubMed).

Trynka, Zhernakova, Romanos et al.: "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. ..." in: Gut, Vol. 58, Issue 8, pp. 1078-83, 2009 (PubMed).

Jeske, So, Kelemen et al.: "Examination of chromosome 7p22 candidate genes RBaK, PMS2 and GNA12 in familial hyperaldosteronism type II." in: Clinical and experimental pharmacology & physiology, Vol. 35, Issue 4, pp. 380-5, 2008 (PubMed).

So, Jeske, Gordon et al.: "No evidence for coding region mutations in the retinoblastoma-associated Kruppel-associated box protein gene (RBaK) causing familial hyperaldosteronism type II." in: Clinical endocrinology, Vol. 65, Issue 6, pp. 829-31, 2006 (PubMed).

Kimura, Wakamatsu, Suzuki et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Catalog No. ABIN394427
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