T-Box 2 (TBX2) antibody

Antigen: T-Box 2 (TBX2)

Synonyms: FLJ10169, tbx2, Xltbx2, TBX2

Clonality: Monoclonal (7G5)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Immunofluorescence (IF), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN394433

Additional Information

Alternative name: TBX2

Gene ID: 6909

UniProt: NP_005985

Immunogen: TBX2 (NP_005985, 603 a.a. ~ 703 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG3 kappa

Clone: 7G5

Description: Other names: FLJ10169 T-box 2

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: TBX2 (NP_005985, 603 a.a. ~ 703 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 74068 DA

Comments:

Background: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cancer, Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Images

Immunofluorescence of monoclonal antibody to TBX2 (AT4166a) on HeLa cell . [antibody concentration 30 ug/ml] Western Blot analysis of TBX2 expression in transfected 293T cell line by TBX2 monoclonal antibody (M01), clone 7G5. Lane 1: TBX2 transfected lysate(74.1 KDa). Lane 2: Non-transfected lysate.

anti-T-Box 2 (TBX2) antibody (Image 2)

Publications

Product: Teng, Ballim, Mowla et al.: "Phosphorylation of histone H3 by protein kinase C signaling plays a critical role in the regulation of the developmentally important TBX2 gene." in: The Journal of biological chemistry, Vol. 284, Issue 39, pp. 26368-76, 2009 (PubMed).

Kim, Lee, Park et al.: "Identification of 15 loci influencing height in a Korean population." in: Journal of human genetics, Vol. 55, Issue 1, pp. 27-31, 2010 (PubMed).

Abrahams, Parker, Prince: "The T-box transcription factor Tbx2: its role in development and possible implication in cancer." in: IUBMB life, Vol. 62, Issue 2, pp. 92-102, 2010 (PubMed).

Liu, Jiang, Zhang: "Expression of PSCA, PIWIL1, and TBX2 in endometrial adenocarcinoma." in: Onkologie, Vol. 33, Issue 5, pp. 241-5, 2010 (PubMed).

Zhao, Li, Bradfield et al.: "The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature." in: BMC medical genetics, Vol. 11, pp. 96, 2010 (PubMed).