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Details for Product No. ABIN394433

T-Box 2 (TBX2) antibody

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Antigen
Synonyms Xltbx2, tbx2, xtbx2, hm:zeh1581, tbx-c, tbxc, zeh1581, TBX2
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN394433
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen TBX2 (NP_005985, 603 a.a. ~ 703 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 7G5
Isotype IgG3 kappa
Specificity TBX2 (NP_005985, 603 a.a. ~ 703 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TBX2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 74068 DA
Gene ID 12406
UniProt NP_005985
Research Area Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence
Comment

Background: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Teng, Ballim, Mowla et al.: "Phosphorylation of histone H3 by protein kinase C signaling plays a critical role in the regulation of the developmentally important TBX2 gene." in: The Journal of biological chemistry, Vol. 284, Issue 39, pp. 26368-76, 2009 (PubMed).

Kim, Lee, Park et al.: "Identification of 15 loci influencing height in a Korean population." in: Journal of human genetics, Vol. 55, Issue 1, pp. 27-31, 2010 (PubMed).

Abrahams, Parker, Prince: "The T-box transcription factor Tbx2: its role in development and possible implication in cancer." in: IUBMB life, Vol. 62, Issue 2, pp. 92-102, 2010 (PubMed).

Liu, Jiang, Zhang: "Expression of PSCA, PIWIL1, and TBX2 in endometrial adenocarcinoma." in: Onkologie, Vol. 33, Issue 5, pp. 241-5, 2010 (PubMed).

Zhao, Li, Bradfield et al.: "The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature." in: BMC medical genetics, Vol. 11, pp. 96, 2010 (PubMed).

Alternatives for antigen "T-Box 2 (TBX2)", type "Antibodies"
Hosts (50), (8), (2)
Reactivities (59), (35), (27), (15), (14), (1), (1), (1), (1)
Applications (35), (29), (20), (11), (5), (5), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (4), (3), (3), (3), (2), (2), (1), (1), (1), (1)
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