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Integrin, alpha 7 (ITGA7) (174869) antibody

Details for Product No. ABIN394439
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Antigen
Synonyms [a]7, alpha7
Reactivity
Human
(38), (26), (20), (17), (17)
Host
Mouse
(35), (12)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(25), (23), (20), (14), (3), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394439
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen ITGA7 (NP_002197, 478 a.a. ~ 578 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 8G2
Isotype IgG2a kappa
Specificity ITGA7 (NP_002197, 478 a.a. ~ 578 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ITGA7
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 128929 DA
Gene ID 12406
UniProt NP_002197
Research Area Translation Factors, Cell Signaling, Cell Structure, Signaling
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Integrin, alpha 7 (ITGA7) (174869) antibody ITGA7 monoclonal antibody (M01), clone 8G2 Western Blot analysis of ITGA7 expression in Jurkat. Detection limit for recombinant GST tagged ITGA7 is approximately 0.1 ng/mL as a capture antibody.
anti-Integrin, alpha 7 (ITGA7) (174869) antibody (2) anti-Integrin, alpha 7 (ITGA7) (174869) antibody (Image 2)
Background publications Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Liu, Gurpur, Kaufman: "Genetically determined proteolytic cleavage modulates alpha7beta1 integrin function." in: The Journal of biological chemistry, Vol. 283, Issue 51, pp. 35668-78, 2008 (PubMed).

Rooney, Gurpur, Burkin: "Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 19, pp. 7991-6, 2009 (PubMed).

Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

Han, Yu, Nelson et al.: "Interaction of integrin-linked kinase and miniature chromosome maintenance 7-mediating integrin {alpha}7 induced cell growth suppression." in: Cancer research, Vol. 70, Issue 11, pp. 4375-84, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN394439
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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