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Details for Product No. ABIN394439

Integrin, alpha 7 (ITGA7) (174869) antibody

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Antigen
Synonyms [a]7, alpha7
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN394439
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen ITGA7 (NP_002197, 478 a.a. ~ 578 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 8G2
Isotype IgG2a kappa
Specificity ITGA7 (NP_002197, 478 a.a. ~ 578 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ITGA7
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 128929 DA
Gene ID 12406
UniProt NP_002197
Research Area Translation Factors, Cell Signaling, Cell Structure, Signaling
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Liu, Gurpur, Kaufman: "Genetically determined proteolytic cleavage modulates alpha7beta1 integrin function." in: The Journal of biological chemistry, Vol. 283, Issue 51, pp. 35668-78, 2008 (PubMed).

Rooney, Gurpur, Burkin: "Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 19, pp. 7991-6, 2009 (PubMed).

Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

Han, Yu, Nelson et al.: "Interaction of integrin-linked kinase and miniature chromosome maintenance 7-mediating integrin {alpha}7 induced cell growth suppression." in: Cancer research, Vol. 70, Issue 11, pp. 4375-84, 2010 (PubMed).

Alternatives for antigen "Integrin, alpha 7 (ITGA7) (174869)", type "Antibodies"
Hosts (29), (12)
Reactivities (32), (26), (20), (17), (17)
Applications (22), (19), (12), (10), (3), (2), (1), (1)
Conjugates (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (4), (4), (4), (2), (2), (1)
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