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ATF3 antibody (Activating Transcription Factor 3) (AA 1-182)

Details for Product anti-ATF3 Antibody No. ABIN394440, Supplier: Login to see New
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Synonyms zgc:55526, ATF3, LRG-21, LRF-1, LRFI, atf-3
AA 1-182
(24), (13), (13), (12), (11), (7), (7), (5), (3), (1), (1), (1), (1), (1), (1)
(108), (32), (28), (4), (4), (4), (2), (1), (1)
(81), (23), (7)
Clonality (Clone)
Monoclonal ()
This ATF3 antibody is un-conjugated
(3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(77), (50), (18), (18), (13), (12), (7), (5), (3), (3), (2), (2), (2), (1), (1), (1)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen ATF3 (AAH06322, 1 a.a. ~ 182 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 8G5
Isotype IgG3 kappa
Specificity ATF3 (AAH06322, 1 a.a. ~ 182 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ATF3 (ATF3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 20576 DA
Gene ID 12406
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000

Background: Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.

Restrictions For Research Use only
Concentration 0.5mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-ATF3 antibody (Activating Transcription Factor 3) (AA 1-182) (ABIN394440) ATF3 monoclonal antibody (M04), clone 8G5 Western Blot analysis of ATF3 expression in...
Immunohistochemistry (IHC) image for anti-ATF3 antibody (Activating Transcription Factor 3) (AA 1-182) (ABIN394440) anti-Activating Transcription Factor 3 (ATF3) (AA 1-182) antibody (Image 2)
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Wu, Nguyen, Dziunycz et al.: "Opposing roles for calcineurin and ATF3 in squamous skin cancer." in: Nature, Vol. 465, Issue 7296, pp. 368-72, 2010 (PubMed).

Koh, Lim, Joe et al.: "AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in HepG2 human hepatocyte cells." in: The FEBS journal, Vol. 277, Issue 10, pp. 2304-17, 2010 (PubMed).

Nguyen, Johnsen, Knetter et al.: "Differential gene expression downstream of Toll-like receptors (TLRs): role of c-Src and activating transcription factor 3 (ATF3)." in: The Journal of biological chemistry, Vol. 285, Issue 22, pp. 17011-9, 2010 (PubMed).

Filén, Ylikoski, Tripathi et al.: "Activating transcription factor 3 is a positive regulator of human IFNG gene expression." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 9, pp. 4990-9, 2010 (PubMed).

Catalog No. ABIN394440
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