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Vav 1 Oncogene (VAV1) (AA 681-791) antibody

Details for Product No. ABIN394445
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Antigen
Synonyms VAV, Vav, vav-T
Epitope
AA 681-791
(43), (20), (16), (7), (7), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(146), (92), (89), (36), (25), (13), (1)
Host
Mouse
(130), (16)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
Immunofluorescence (IF), Western Blotting (WB)
(110), (56), (30), (22), (12), (8), (7), (4), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394445
450.00 $
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Immunogen VAV1 (AAH13361, 681 a.a. ~ 791 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 9C1
Isotype IgG2b kappa
Specificity VAV1 (AAH13361, 681 a.a. ~ 791 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name VAV1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 98314 DA
Gene ID 12406
Research Area Cell Signaling, Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Vav 1 Oncogene (VAV1) (AA 681-791) antibody Immunofluorescence of monoclonal antibody to VAV1 on HeLa cell (antibody concentration 10 µg/mL). VAV1 monoclonal antibody (M01), clone 9C1 Western Blot analysis of VAV1 expression in Jurkat.
anti-Vav 1 Oncogene (VAV1) (AA 681-791) antibody (2) anti-Vav 1 Oncogene (VAV1) (AA 681-791) antibody (Image 2)
Background publications Yu, Martins, Li et al.: "Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1." in: Cell, Vol. 140, Issue 2, pp. 246-56, 2010 (PubMed).

Kim, Das, Gross et al.: "Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase." in: Immunity, Vol. 32, Issue 2, pp. 175-86, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Barda-Saad, Shirasu, Pauker et al.: "Cooperative interactions at the SLP-76 complex are critical for actin polymerization." in: The EMBO journal, Vol. 29, Issue 14, pp. 2315-28, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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