You are viewing an incomplete version of our website. Please click to reload the website as full version.

BPNT1 antibody (3'(2'), 5'-Bisphosphate Nucleotidase 1) (AA 1-101)

Details for Product anti-BPNT1 Antibody No. ABIN394459, Supplier: Login to see
Antigen
  • BPNT1
  • PIP
  • Sal3
  • BPntase
Epitope
AA 1-101
22
16
13
4
3
2
2
2
2
1
1
Reactivity
Human
57
20
19
2
2
1
Host
Mouse
43
7
7
Clonality (Clone)
Monoclonal ()
Conjugate
This BPNT1 antibody is un-conjugated
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
43
25
12
6
5
3
2
Supplier
Login to see
Supplier Product No.
Login to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Available images

Immunogen BPNT1 (NP_006076, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E1
Isotype IgG1 kappa
Specificity BPNT1 (NP_006076, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BPNT1 (BPNT1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 33392 DA
Gene ID 12406
NCBI Accession NP_006076
Research Area Cell Signaling, Metabolism, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-BPNT1 antibody (3'(2'), 5'-Bisphosphate Nucleotidase 1) (AA 1-101) (ABIN394459) Immunofluorescence of monoclonal antibody to BPNT1 on HeLa cell (antibody concentrati...
Immunohistochemistry (IHC) image for anti-BPNT1 antibody (3'(2'), 5'-Bisphosphate Nucleotidase 1) (AA 1-101) (ABIN394459) anti-3'(2'), 5'-Bisphosphate Nucleotidase 1 (BPNT1) (AA 1-101) antibody (Image 2)
Background publications Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Spiegelberg, Xiong, Smith et al.: "Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate." in: The Journal of biological chemistry, Vol. 274, Issue 19, pp. 13619-28, 1999 (PubMed).