Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) (AA 1726-1792) antibody

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Antigen
Synonyms SCN11A, NSS2, NaN, NaT, SNS2, NAV1.9, SCN12A, SNS-2
Epitope
AA 1726-1792
(3), (2), (1)
Reactivity
Human
(18), (14), (13), (12), (12), (12), (12)
Host
Mouse
(18), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(10), (10), (4), (3), (3), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394475
450.00 $
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Immunogen SCN11A (NP_054858, 1726 a.a. ~ 1792 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6E1
Isotype IgG2a kappa
Specificity SCN11A (NP_054858, 1726 a.a. ~ 1792 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SCN11A
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 204922 DA
Gene ID 12406
NCBI Accession NP_054858
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops, each domain consists of 6 transmembrane segments and intra- and extracellular linkers.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) (AA 1726-1792) antibody Detection limit for recombinant GST tagged SCN11A is approximately 0.03 ng/mL as a capture antibody.
Background publications Goldin, Barchi, Caldwell et al.: "Nomenclature of voltage-gated sodium channels." in: Neuron, Vol. 28, Issue 2, pp. 365-8, 2000 (PubMed).

Blum, Kafitz, Konnerth: "Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9." in: Nature, Vol. 419, Issue 6908, pp. 687-93, 2002 (PubMed).

Delmas, Coste: "Na+ channel Nav1.9: in search of a gating mechanism." in: Trends in neurosciences, Vol. 26, Issue 2, pp. 55-7, 2003 (PubMed).

Raymond, Castle, Garrett-Engele et al.: "Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia." in: The Journal of biological chemistry, Vol. 279, Issue 44, pp. 46234-41, 2004 (PubMed).

Catterall, Goldin, Waxman: "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 397-409, 2005 (PubMed).

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