Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) (AA 1726-1792) antibody

Details for Product No. ABIN394475, Supplier: Log in to see
  • SCN11A
  • NSS2
  • NaN
  • NaT
  • SNS2
  • NAV1.9
  • SCN12A
  • SNS-2
  • sodium channel, voltage-gated, type XI, alpha subunit
  • sodium channel, voltage-gated, type XI, alpha
  • SCN11A
  • Scn11a
AA 1726-1792
Clonality (Clone)
Monoclonal ()
ELISA, Western Blotting (WB)
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Immunogen SCN11A (NP_054858, 1726 a.a. ~ 1792 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6E1
Isotype IgG2a kappa
Specificity SCN11A (NP_054858, 1726 a.a. ~ 1792 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SCN11A (SCN11A Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 204922 DA
Gene ID 12406
NCBI Accession NP_054858
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops, each domain consists of 6 transmembrane segments and intra- and extracellular linkers.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) (AA 1726-1792) antibody (ABIN394475) Detection limit for recombinant GST tagged SCN11A is approximately 0.03 ng/mL as a ca...
Background publications Catterall, Goldin, Waxman: "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 397-409, 2005 (PubMed).

Raymond, Castle, Garrett-Engele, Armour, Kan, Tsinoremas, Johnson: "Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia." in: The Journal of biological chemistry, Vol. 279, Issue 44, pp. 46234-41, 2004 (PubMed).

Delmas, Coste: "Na+ channel Nav1.9: in search of a gating mechanism." in: Trends in neurosciences, Vol. 26, Issue 2, pp. 55-7, 2003 (PubMed).

Blum, Kafitz, Konnerth: "Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9." in: Nature, Vol. 419, Issue 6908, pp. 687-93, 2002 (PubMed).

Goldin, Barchi, Caldwell, Hofmann, Howe, Hunter, Kallen, Mandel, Meisler, Netter, Noda, Tamkun, Waxman, Wood, Catterall: "Nomenclature of voltage-gated sodium channels." in: Neuron, Vol. 28, Issue 2, pp. 365-8, 2000 (PubMed).

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