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GBA antibody (Glucosidase, Beta, Acid) (AA 146-236)

Details for Product anti-GBA Antibody No. ABIN394481, Supplier: Login to see
Antigen
  • BETA-GLUCOSIDASE
  • GLUC
  • T12J13.8
  • T12J13_8
  • beta glucosidase 25
  • PSPTO3318
  • PSPTO4290
  • GBA1
  • GCB
  • GC
  • GCase
  • betaGC
Epitope
AA 146-236
12
7
7
6
5
5
5
5
4
3
3
2
2
1
1
1
Reactivity
Human
65
10
7
3
Host
Mouse
55
25
Clonality (Clone)
Monoclonal ()
Conjugate
This GBA antibody is un-conjugated
7
5
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
58
33
19
12
10
6
4
2
2
2
2
1
1
1
Supplier
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Immunogen GBA (NP_000148, 146 a.a. ~ 236 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E2
Isotype IgG2a kappa
Specificity GBA (NP_000148, 146 a.a. ~ 236 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GBA (GBA Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 59716 DA
Gene ID 12406
NCBI Accession NP_000148
Research Area Cell Structure, Metabolism
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-GBA antibody (Glucosidase, Beta, Acid) (AA 146-236) (ABIN394481) Immunofluorescence of monoclonal antibody to GBA on HeLa cell (antibody concentration...
Immunohistochemistry (IHC) image for anti-GBA antibody (Glucosidase, Beta, Acid) (AA 146-236) (ABIN394481) anti-Glucosidase, Beta, Acid (GBA) (AA 146-236) antibody (Image 2)
Background publications Dos Santos, Pestana, Diniz et al.: "Mutational analysis of GIGYF2, ATP13A2 and GBA genes in Brazilian patients with early-onset Parkinson's disease." in: Neuroscience letters, Vol. 485, Issue 2, pp. 121-4, 2010 (PubMed).

Jeong, Park, Kim: "Clinical and genetic characteristics of Korean patients with Gaucher disease." in: Blood cells, molecules & diseases, Vol. 46, Issue 1, pp. 11-4, 2011 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Hu, Xi, Guo et al.: "Association of the glucocerebrosidase N370S allele with Parkinson's disease in two separate Chinese Han populations of mainland China." in: European journal of neurology : the official journal of the European Federation of Neurological Societies, Vol. 17, Issue 12, pp. 1476-8, 2010 (PubMed).

Velayati, Yu, Sidransky: "The role of glucocerebrosidase mutations in Parkinson disease and Lewy body disorders." in: Current neurology and neuroscience reports, Vol. 10, Issue 3, pp. 190-8, 2010 (PubMed).