You are viewing an incomplete version of our website. Please click to reload the website as full version.

GBA antibody (Glucosidase, Beta, Acid) (AA 146-236)

Details for Product anti-GBA Antibody No. ABIN394481, Supplier: Login to see New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms BETA-GLUCOSIDASE, GLUC, T12J13.8, T12J13_8, beta glucosidase 25, PSPTO3318, PSPTO4290, GBA1, GCB, GC, GCase, betaGC
AA 146-236
(12), (7), (7), (7), (6), (6), (6), (5), (4), (3), (3), (2), (2), (1), (1), (1)
(67), (11), (8), (3)
(59), (25)
Clonality (Clone)
Monoclonal ()
This GBA antibody is un-conjugated
(8), (5), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(63), (38), (23), (13), (10), (10), (8), (2), (2), (2), (2), (1), (1), (1)
Pubmed 5 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen GBA (NP_000148, 146 a.a. ~ 236 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E2
Isotype IgG2a kappa
Specificity GBA (NP_000148, 146 a.a. ~ 236 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GBA (GBA Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 59716 DA
Gene ID 12406
NCBI Accession NP_000148
Research Area Cell Structure, Metabolism
Application Notes Western blot = 1:500-1000

Background: This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-GBA antibody (Glucosidase, Beta, Acid) (AA 146-236) (ABIN394481) Immunofluorescence of monoclonal antibody to GBA on HeLa cell (antibody concentration...
Immunohistochemistry (IHC) image for anti-GBA antibody (Glucosidase, Beta, Acid) (AA 146-236) (ABIN394481) anti-Glucosidase, Beta, Acid (GBA) (AA 146-236) antibody (Image 2)
Background publications Dos Santos, Pestana, Diniz et al.: "Mutational analysis of GIGYF2, ATP13A2 and GBA genes in Brazilian patients with early-onset Parkinson's disease." in: Neuroscience letters, Vol. 485, Issue 2, pp. 121-4, 2010 (PubMed).

Jeong, Park, Kim: "Clinical and genetic characteristics of Korean patients with Gaucher disease." in: Blood cells, molecules & diseases, Vol. 46, Issue 1, pp. 11-4, 2011 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Hu, Xi, Guo et al.: "Association of the glucocerebrosidase N370S allele with Parkinson's disease in two separate Chinese Han populations of mainland China." in: European journal of neurology : the official journal of the European Federation of Neurological Societies, Vol. 17, Issue 12, pp. 1476-8, 2010 (PubMed).

Velayati, Yu, Sidransky: "The role of glucocerebrosidase mutations in Parkinson disease and Lewy body disorders." in: Current neurology and neuroscience reports, Vol. 10, Issue 3, pp. 190-8, 2010 (PubMed).

Catalog No. ABIN394481
Plus shipping costs $45.00

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)