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Details for Product No. ABIN394481

Glucosidase, Beta, Acid (GBA) antibody

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Antigen
Synonyms GCB, GBA1, GLUC, GC, GCase, betaGC, BETA-GLUCOSIDASE, T12J13.8, T12J13_8, beta glucosidase 25, PSPTO3318, PSPTO4290
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN394481
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen GBA (NP_000148, 146 a.a. ~ 236 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E2
Isotype IgG2a kappa
Specificity GBA (NP_000148, 146 a.a. ~ 236 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GBA
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 59716 DA
Gene ID 12406
UniProt NP_000148
Research Area Cell Structure, Metabolism
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml Immunofluorescence
Comment

Background: This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Velayati, Yu, Sidransky: "The role of glucocerebrosidase mutations in Parkinson disease and Lewy body disorders." in: Current neurology and neuroscience reports, Vol. 10, Issue 3, pp. 190-8, 2010 (PubMed).

Hu, Xi, Guo et al.: "Association of the glucocerebrosidase N370S allele with Parkinson's disease in two separate Chinese Han populations of mainland China." in: European journal of neurology : the official journal of the European Federation of Neurological Societies, Vol. 17, Issue 12, pp. 1476-8, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Jeong, Park, Kim: "Clinical and genetic characteristics of Korean patients with Gaucher disease." in: Blood cells, molecules & diseases, Vol. 46, Issue 1, pp. 11-4, 2011 (PubMed).

Dos Santos, Pestana, Diniz et al.: "Mutational analysis of GIGYF2, ATP13A2 and GBA genes in Brazilian patients with early-onset Parkinson's disease." in: Neuroscience letters, Vol. 485, Issue 2, pp. 121-4, 2010 (PubMed).

Alternatives for antigen "Glucosidase, Beta, Acid (GBA)", type "Antibodies"
Hosts (30), (8)
Reactivities (36), (13), (12), (3)
Applications (28), (16), (10), (10), (6), (6), (3), (2), (2), (1), (1)
Conjugates (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (3), (3), (2), (1), (1), (1), (1)
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