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Tafazzin (TAZ) (Met20) antibody

Details for Product No. ABIN394550, Supplier: Login to see
Antigen
  • wu:fb39f12
  • zgc:91803
  • MGC54019
  • TAZ
  • taz
  • GB11956
  • Afu2g13960
  • BTHS
  • CMD3A
  • EFE
  • EFE2
  • G4.5
  • LVNCX
  • Taz1
  • 5031411C02Rik
  • 9130012G04Rik
  • AW107266
  • AW552613
Epitope
Met20
21
19
13
11
11
5
5
5
5
3
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
124
32
32
3
2
1
1
Host
Mouse
100
18
16
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
9
8
6
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
Application
ELISA
94
63
22
16
9
7
6
4
4
3
2
1
1
Supplier
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Immunogen TAZ (AAH11515, 1 a.a. ~ 263 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1E5
Isotype IgG2a kappa
Specificity TAZ (AAH11515, 1 a.a. ~ 263 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TAZ (TAZ Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight NONE?! DA
Gene ID 12406
Research Area Cell Structure
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced, the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Tafazzin (TAZ) (Met20) antibody (ABIN394550) Detection limit for recombinant GST tagged TAZ is approximately 3 ng/mL as a capture ...
Background publications Zimmerman, Cox, Lakdawala et al.: "A novel custom resequencing array for dilated cardiomyopathy." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 12, Issue 5, pp. 268-78, 2010 (PubMed).

Strakova, Reed, Ihnatovych: "Human transcriptional coactivator with PDZ-binding motif (TAZ) is downregulated during decidualization." in: Biology of reproduction, Vol. 82, Issue 6, pp. 1112-8, 2010 (PubMed).

Xu, Zhang, Malhotra et al.: "Characterization of tafazzin splice variants from humans and fruit flies." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 29230-9, 2009 (PubMed).

Ferrara, De Sanctis, Rossi et al.: "Mutations in TAZ/WWTR1, a co-activator of NKX2.1 and PAX8 are not a frequent cause of thyroid dysgenesis." in: Journal of endocrinological investigation, Vol. 32, Issue 3, pp. 238-41, 2009 (PubMed).

Zhang, Liu, Zha et al.: "TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition." in: The Journal of biological chemistry, Vol. 284, Issue 20, pp. 13355-62, 2009 (PubMed).

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