Tafazzin (TAZ) (Met20) antibody

Details for Product No. ABIN394550
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Antigen
Synonyms wu:fb39f12, zgc:91803, MGC54019, TAZ, taz, GB11956, Afu2g13960, BTHS, CMD3A, EFE, EFE2, G4.5, LVNCX, Taz1, 5031411C02Rik, 9130012G04Rik, AW107266, AW552613
Epitope
Met20
(12), (11), (6), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(81), (23), (21), (3), (2), (2)
Host
Mouse
(66), (15), (5), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application
ELISA
(58), (38), (20), (12), (7), (4), (3), (3), (3), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394550
450.00 $
Plus shipping costs $45.00

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Immunogen TAZ (AAH11515, 1 a.a. ~ 263 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1E5
Isotype IgG2a kappa
Specificity TAZ (AAH11515, 1 a.a. ~ 263 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TAZ
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight NONE?! DA
Gene ID 12406
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced, the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Tafazzin (TAZ) (Met20) antibody Detection limit for recombinant GST tagged TAZ is approximately 3 ng/mL as a capture antibody.
Background publications Zhang, Liu, Zha et al.: "TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition." in: The Journal of biological chemistry, Vol. 284, Issue 20, pp. 13355-62, 2009 (PubMed).

Ferrara, De Sanctis, Rossi et al.: "Mutations in TAZ/WWTR1, a co-activator of NKX2.1 and PAX8 are not a frequent cause of thyroid dysgenesis." in: Journal of endocrinological investigation, Vol. 32, Issue 3, pp. 238-41, 2009 (PubMed).

Xu, Zhang, Malhotra et al.: "Characterization of tafazzin splice variants from humans and fruit flies." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 29230-9, 2009 (PubMed).

Strakova, Reed, Ihnatovych: "Human transcriptional coactivator with PDZ-binding motif (TAZ) is downregulated during decidualization." in: Biology of reproduction, Vol. 82, Issue 6, pp. 1112-8, 2010 (PubMed).

Zimmerman, Cox, Lakdawala et al.: "A novel custom resequencing array for dilated cardiomyopathy." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 12, Issue 5, pp. 268-78, 2010 (PubMed).

Validation Images
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