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APOL3 antibody (Apolipoprotein L, 3) (AA 240-337)

Details for Product anti-APOL3 Antibody No. ABIN394564, Supplier: Log in to see
Antigen
  • CG121
  • APOLIII
  • APOL3
  • apolipoprotein L, 3
  • similar to apolipoprotein L2; apolipoprotein L-II
  • APOL3
  • Apol3
  • RGD1309808
Epitope
AA 240-337
13
9
3
3
3
2
2
1
1
1
1
1
1
1
Reactivity
Human
42
3
3
Host
Mouse
17
15
10
Clonality (Clone)
Monoclonal ()
Conjugate
This APOL3 antibody is un-conjugated
2
2
2
2
2
2
Application
ELISA, Western Blotting (WB)
39
26
3
2
1
1
1
Options
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Immunogen APOL3 (NP_663615, 240 a.a. ~ 337 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4E5
Isotype IgG2a kappa
Specificity APOL3 (NP_663615, 240 a.a. ~ 337 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name APOL3 (APOL3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 44347 DA
Gene ID 12406
NCBI Accession NP_663615
Research Area Cancer, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 6. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-APOL3 antibody (Apolipoprotein L, 3) (AA 240-337) (ABIN394564) Detection limit for recombinant GST tagged APOL3 is approximately 0.03 ng/mL as a cap...
Background publications Johanneson, McDonnell, Karyadi, Quignon, McIntosh, Riska, FitzGerald, Johnson, Deutsch, Williams, Tillmans, Stanford, Schaid, Thibodeau, Ostrander: "Family-based association analysis of 42 hereditary prostate cancer families identifies the Apolipoprotein L3 region on chromosome 22q12 as a risk locus." in: Human molecular genetics, Vol. 19, Issue 19, pp. 3852-62, 2010 (PubMed).

Ruaño, Thompson, Kane, Pullinger, Windemuth, Seip, Kocherla, Holford, Wu: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Rose, Behm, Drgon, Johnson, Uhl: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Ma, Dempsey, Stamatiou, Marshall, Liew: "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects." in: Atherosclerosis, Vol. 191, Issue 1, pp. 63-72, 2007 (PubMed).