Junctophilin 1 (JPH1) (AA 501-580) antibody

Details for Product No. ABIN394580
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Antigen
Synonyms jph1, bZ1M12.3, si:rp71-1m12.3, JP-1, JP1, ENSMUSG00000054314, Jp1, Jph1
Epitope
AA 501-580
(13), (2)
Reactivity
Human
(16), (10), (9), (2), (2), (1)
Host
Mouse
(14), (2)
Clonality (Clone)
Monoclonal ()
Application
ELISA, Western Blotting (WB)
(16), (10), (6)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394580
450.00 $
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Immunogen JPH1 (NP_065698, 501 a.a. ~ 580 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E6
Isotype IgG2a kappa
Specificity JPH1 (NP_065698, 501 a.a. ~ 580 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name JPH1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 71686 DA
Gene ID 12406
NCBI Accession NP_065698
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Junctophilin 1 (JPH1) (AA 501-580) antibody Detection limit for recombinant GST tagged JPH1 is approximately 0.03 ng/mL as a capture antibody.
Background publications Brandenberger, Wei, Zhang et al.: "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation." in: Nature biotechnology, Vol. 22, Issue 6, pp. 707-16, 2004 (PubMed).

Nusbaum, Mikkelsen, Zody et al.: "DNA sequence and analysis of human chromosome 8." in: Nature, Vol. 439, Issue 7074, pp. 331-5, 2006 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Yamazaki, Yamazaki, Takeshima: "New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes." in: Pharmacology & therapeutics, Vol. 121, Issue 3, pp. 265-72, 2009 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

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