Coagulation Factor VIII (F8) (AA 213-313) antibody

Details for Product No. ABIN394620
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Antigen
Synonyms fb61d02, wu:fb61d02, Cf-8, Cf8, FVIII, AHF, DXS1253E, F8B, F8C, HEMA
Epitope
AA 213-313
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(46), (3), (2), (1), (1)
Host
Mouse
(35), (16), (1), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1)
Application
ELISA
(40), (39), (10), (9), (8), (4), (4), (2), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394620
450.00 $
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Immunogen F8 (NP_000123, 213 a.a. ~ 313 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1E8
Isotype IgG2b kappa
Specificity F8 (NP_000123, 213 a.a. ~ 313 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name F8
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 267009 DA
Gene ID 12406
NCBI Accession NP_000123
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Coagulation Factor VIII (F8) (AA 213-313) antibody Detection limit for recombinant GST tagged F8 is approximately 3 ng/mL as a capture antibody.
Background publications Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Shahani, Lavendhomme, Luttun et al.: "Activation of human endothelial cells from specific vascular beds induces the release of a FVIII storage pool." in: Blood, Vol. 115, Issue 23, pp. 4902-9, 2010 (PubMed).

Hernández-Romero, Marín, Lee et al.: "Synergism between factor XII -4C>T and factor XIII Val34Leu polymorphisms in fibrinolytic therapy in acute myocardial infarction." in: Thrombosis and haemostasis, Vol. 104, Issue 3, pp. 650-2, 2010 (PubMed).

Shemirani, Pongrácz, Antalfi et al.: "Factor XIII A subunit Val34Leu polymorphism in patients suffering atherothrombotic ischemic stroke." in: Thrombosis research, Vol. 126, Issue 2, pp. 159-62, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

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