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Factor VIII antibody (Coagulation Factor VIII) (AA 213-313)

Details for Product anti-F8 Antibody No. ABIN394620, Supplier: Login to see
Antigen
  • fb61d02
  • wu:fb61d02
  • Cf-8
  • Cf8
  • FVIII
  • AHF
  • DXS1253E
  • F8B
  • F8C
  • HEMA
Epitope
AA 213-313
13
13
6
6
6
5
5
5
4
3
3
3
2
2
2
2
1
1
1
1
1
Reactivity
Human
236
34
18
13
9
1
1
Host
Mouse
131
99
27
5
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Factor VIII antibody is un-conjugated
12
12
9
6
3
2
2
2
2
2
2
2
2
2
2
Application
ELISA
151
146
29
24
23
12
11
10
8
6
3
3
3
3
2
2
2
1
1
1
1
1
Supplier
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Immunogen F8 (NP_000123, 213 a.a. ~ 313 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1E8
Isotype IgG2b kappa
Specificity F8 (NP_000123, 213 a.a. ~ 313 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name F8 (F8 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 267009 DA
Gene ID 12406
NCBI Accession NP_000123
Research Area Cell Structure
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Factor VIII antibody (Coagulation Factor VIII) (AA 213-313) (ABIN394620) Detection limit for recombinant GST tagged F8 is approximately 3 ng/mL as a capture a...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Shemirani, Pongrácz, Antalfi et al.: "Factor XIII A subunit Val34Leu polymorphism in patients suffering atherothrombotic ischemic stroke." in: Thrombosis research, Vol. 126, Issue 2, pp. 159-62, 2010 (PubMed).

Hernández-Romero, Marín, Lee et al.: "Synergism between factor XII -4C>T and factor XIII Val34Leu polymorphisms in fibrinolytic therapy in acute myocardial infarction." in: Thrombosis and haemostasis, Vol. 104, Issue 3, pp. 650-2, 2010 (PubMed).

Shahani, Lavendhomme, Luttun et al.: "Activation of human endothelial cells from specific vascular beds induces the release of a FVIII storage pool." in: Blood, Vol. 115, Issue 23, pp. 4902-9, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).