Lipase, Gastric (LIPF) antibody

Details for Product No. ABIN394627
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Antigen
Synonyms GL, HGL, HLAL, Rnlp, RNLIP, AV082900, 2310051B21Rik, DGL, fb73g06, zgc:56632, wu:fb73g06, LIPF
Reactivity
Human
(15), (7), (1), (1), (1), (1)
Host
Mouse
(12), (4), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(17), (10), (5), (5), (5), (1)
Pubmed 5 references available
Catalog no. ABIN394627
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen LIPF (NP_004181, 299 a.a. ~ 399 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E8
Isotype IgG1 kappa
Specificity LIPF (NP_004181, 299 a.a. ~ 399 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name LIPF
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 45238 DA
Gene ID 12406
UniProt NP_004181
Research Area Metabolism, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Lipase, Gastric (LIPF) antibody Detection limit for recombinant GST tagged LIPF is approximately 0.03 ng/mL as a capture antibody.
Background publications Ruaño, Bernene, Windemuth et al.: "Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone." in: Clinica chimica acta; international journal of clinical chemistry, Vol. 400, Issue 1-2, pp. 48-55, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Zhang, Yang, Kim et al.: "An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer." in: International journal of oncology, Vol. 36, Issue 2, pp. 405-14, 2009 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Hosts (12), (4), (4)
Reactivities (15), (7), (1), (1), (1), (1)
Applications (17), (10), (5), (5), (5), (1)
Conjugates (2), (1), (1), (1), (1), (1)
Epitopes (5), (2), (2), (2)
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