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Vimentin (VIM) (AA 41-141) antibody

Details for Product No. ABIN394656
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Antigen
Synonyms vime, CTRCT30, cb28, vim, vim1, vim2, VIM, Vimentin
Epitope
AA 41-141
(20), (18), (16), (15), (10), (8), (8), (7), (5), (5), (5), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(461), (159), (148), (85), (78), (53), (41), (18), (12), (11), (10), (9), (6), (5), (5), (2), (2), (1), (1), (1), (1), (1), (1)
Host
Mouse
(246), (224), (26), (9), (7), (5), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(20), (19), (12), (6), (5), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (2), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(382), (162), (157), (143), (101), (92), (61), (49), (40), (34), (3), (3), (3), (2), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN394656
450.00 $
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Immunogen VIM (AAH30573, 41 a.a. ~ 141 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3E9
Isotype IgG2a kappa
Specificity VIM (AAH30573, 41 a.a. ~ 141 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name VIM
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 53652 DA
Gene ID 12406
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Vimentin (VIM) (AA 41-141) antibody Immunofluorescence of monoclonal antibody to VIM on HeLa cell (antibody concentration 40 µg/mL). VIM monoclonal antibody (M01), clone 3E9 Western Blot analysis of VIM expression in HeLa.
anti-Vimentin (VIM) (AA 41-141) antibody (2) anti-Vimentin (VIM) (AA 41-141) antibody (Image 2)
Background publications Stewart, Little: "Diagnostic value and implications of vimentin expression in normal, reactive and neoplastic endocervical epithelium." in: Pathology, Vol. 42, Issue 3, pp. 217-23, 2010 (PubMed).

Lin, Broedersz, Rowat et al.: "Divalent cations crosslink vimentin intermediate filament tail domains to regulate network mechanics." in: Journal of molecular biology, Vol. 399, Issue 4, pp. 637-44, 2010 (PubMed).

Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

Martins-de-Souza, Maccarrone, Wobrock et al.: "Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia." in: Journal of psychiatric research, Vol. 44, Issue 16, pp. 1176-89, 2010 (PubMed).

Korita, Wakai, Ajioka et al.: "Aberrant expression of vimentin correlates with dedifferentiation and poor prognosis in patients with intrahepatic cholangiocarcinoma." in: Anticancer research, Vol. 30, Issue 6, pp. 2279-85, 2010 (PubMed).

Validation Images
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