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ATP-Binding Cassette, Sub-Family G (WHITE), Member 1 (ABCG1) (AA 21-130) antibody

Details for Product No. ABIN394690, Supplier: Log in to see
Antigen
  • ABCG1
  • zgc:162197
  • ABC8
  • WHITE1
  • AW413978
  • Abc8
  • White
Epitope
AA 21-130
8
8
6
5
4
4
3
3
3
2
2
1
1
1
1
1
1
Reactivity
Human
70
33
26
Host
Mouse
68
4
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
3
2
1
1
1
1
1
1
1
1
1
Application
ELISA
49
27
26
11
11
8
5
1
1
1
Supplier
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Immunogen ABCG1 (AAH29158, 21 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E11
Isotype IgG1 lambda
Specificity ABCG1 (AAH29158, 21 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ABCG1 (ABCG1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 75592 DA
Gene ID 12406
Research Area Cell Structure
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-ATP-Binding Cassette, Sub-Family G (WHITE), Member 1 (ABCG1) (AA 21-130) antibody (ABIN394690) Detection limit for recombinant GST tagged ABCG1 is approximately 0.1 ng/mL as a capt...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Li, Zhang, Ma et al.: "Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 30, Issue 7, pp. 1354-62, 2010 (PubMed).

Abellán, Mansego, Martínez-Hervás et al.: "Association of selected ABC gene family single nucleotide polymorphisms with postprandial lipoproteins: results from the population-based Hortega study." in: Atherosclerosis, Vol. 211, Issue 1, pp. 203-9, 2010 (PubMed).

Hu, Wang, Ma et al.: "TGF-beta1 up-regulates expression of ABCA1, ABCG1 and SR-BI through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells." in: Journal of atherosclerosis and thrombosis, Vol. 17, Issue 5, pp. 493-502, 2010 (PubMed).

McGeachie, Ramoni, Mychaleckyj et al.: "Integrative predictive model of coronary artery calcification in atherosclerosis." in: Circulation, Vol. 120, Issue 24, pp. 2448-54, 2009 (PubMed).