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ABCG1 antibody (ATP-Binding Cassette, Sub-Family G (WHITE), Member 1) (AA 21-130)

Details for Product anti-ABCG1 Antibody No. ABIN394690, Supplier: Log in to see
Antigen
  • Abc8
  • ABC8
  • ABCG1
  • AW413978
  • White
  • WHITE1
  • zgc:162197
Epitope
AA 21-130
18
12
8
8
6
5
4
4
3
2
2
1
1
1
1
1
1
Reactivity
Human
85
48
34
8
8
8
8
Host
Mouse
83
4
Clonality (Clone)
Monoclonal ()
Conjugate
This ABCG1 antibody is un-conjugated
5
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA
64
41
25
15
11
11
7
4
2
1
1
Supplier
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Immunogen ABCG1 (AAH29158, 21 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E11
Isotype IgG1 lambda
Specificity ABCG1 (AAH29158, 21 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ABCG1 (ABCG1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 75592 DA
Gene ID 12406
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-ABCG1 antibody (ATP-Binding Cassette, Sub-Family G (WHITE), Member 1) (AA 21-130) (ABIN394690) Detection limit for recombinant GST tagged ABCG1 is approximately 0.1 ng/mL as a capt...
Background publications Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010

Li, Zhang, Ma, Ling, Xia: "Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 30, Issue 7, pp. 1354-62, 2010

Abellán, Mansego, Martínez-Hervás, Martín-Escudero, Carmena, Real, Redon, Castrodeza-Sanz, Chaves: "Association of selected ABC gene family single nucleotide polymorphisms with postprandial lipoproteins: results from the population-based Hortega study." in: Atherosclerosis, Vol. 211, Issue 1, pp. 203-9, 2010

Hu, Wang, Ma, Li, Liu, Xiao, Liao, Xiang, Tang: "TGF-beta1 up-regulates expression of ABCA1, ABCG1 and SR-BI through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells." in: Journal of atherosclerosis and thrombosis, Vol. 17, Issue 5, pp. 493-502, 2010

McGeachie, Ramoni, Mychaleckyj, Furie, Dreyfuss, Liu, Herrington, Guo, Lima, Post, Rotter, Rich, Sale, Ramoni: "Integrative predictive model of coronary artery calcification in atherosclerosis." in: Circulation, Vol. 120, Issue 24, pp. 2448-54, 2009