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Glutaminyl-Peptide Cyclotransferase (QPCT) (AA 262-360) antibody

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Synonyms QPCT, GCT, QC, sQC, 5730422A13Rik
AA 262-360
(17), (15), (6), (4), (3), (3), (2), (2), (1), (1), (1), (1)
(57), (2), (1), (1), (1), (1), (1)
(48), (9)
Clonality (Clone)
Monoclonal ()
(6), (5), (5), (2), (2), (2)
ELISA, Western Blotting (WB)
(45), (32), (4), (4), (3), (2), (2), (1), (1)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen QPCT (NP_036545, 262 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4E11
Isotype IgG2a kappa
Specificity QPCT (NP_036545, 262 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name QPCT (QPCT Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 40877 DA
Gene ID 12406
NCBI Accession NP_036545
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Glutaminyl-Peptide Cyclotransferase (QPCT) (AA 262-360) antibody (ABIN394702) Detection limit for recombinant GST tagged QPCT is approximately 0.03 ng/mL as a capt...
Background publications Marroni, Pfeufer, Aulchenko et al.: "A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project." in: Circulation. Cardiovascular genetics, Vol. 2, Issue 4, pp. 322-8, 2009 (PubMed).

Stephan, Wermann, von Bohlen et al.: "Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics." in: The FEBS journal, Vol. 276, Issue 22, pp. 6522-36, 2010 (PubMed).

Cynis, Rahfeld, Stephan et al.: "Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery." in: Journal of molecular biology, Vol. 379, Issue 5, pp. 966-80, 2008 (PubMed).

Calvaresi, Garavelli, Bottoni: "Computational evidence for the catalytic mechanism of glutaminyl cyclase. A DFT investigation." in: Proteins, Vol. 73, Issue 3, pp. 527-38, 2008 (PubMed).

Huang, Wang, Chang et al.: "A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis." in: The Biochemical journal, Vol. 411, Issue 1, pp. 181-90, 2008 (PubMed).

Catalog No. ABIN394702
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