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Ras Homolog Gene Family, Member C (RHOC) (AA 1-194) antibody

Details for Product No. ABIN394719
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Antigen
Synonyms ARHC, LOC100221682, ARH9, H9, RHOH9, AI324259, Arh9, Arhc, CRHOC
Epitope
AA 1-194
(8), (7), (6), (3), (2), (1), (1)
Reactivity
Human
(43), (21), (21), (13), (12), (1), (1), (1)
Host
Mouse
(30), (15)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(35), (22), (11), (10), (4), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN394719
450.00 $
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Immunogen RHOC (AAH07245, 1 a.a. ~ 194 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E12
Isotype IgG2b kappa
Specificity RHOC (AAH07245, 1 a.a. ~ 194 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name RHOC
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 22006 DA
Gene ID 12406
Research Area Cell Signaling, Cell Structure, Cancer, Cell Cycle
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Ras Homolog Gene Family, Member C (RHOC) (AA 1-194) antibody Western Blot analysis of RHOC expression in transfected 293T cell line by RHOC monoclonal antibody (M01), clone 2E12. Lane 1: RHOC transfected lysate(22 KDa). Lane 2: Non-transfected lysate. RHOC monoclonal antibody (M01), clone 2E12 Western Blot analysis of RHOC expression in Jurkat.
anti-Ras Homolog Gene Family, Member C (RHOC) (AA 1-194) antibody (2) anti-Ras Homolog Gene Family, Member C (RHOC) (AA 1-194) antibody (Image 2)
Background publications Segat, Brandão, Guimarães et al.: "Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment." in: Vaccine, Vol. 28, Issue 10, pp. 2201-6, 2010 (PubMed).

Kitzing, Wang, Pertz et al.: "Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC." in: Oncogene, Vol. 29, Issue 16, pp. 2441-8, 2010 (PubMed).

Jiang, Liu, Kolokythas et al.: "Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma." in: International journal of cancer. Journal international du cancer, Vol. 127, Issue 3, pp. 505-12, 2010 (PubMed).

Lipkin, Chao, Moreno et al.: "Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer." in: Cancer prevention research (Philadelphia, Pa.), Vol. 3, Issue 5, pp. 597-603, 2010 (PubMed).

Wu, Wu, Rosenthal et al.: "Characterization of the roles of RHOC and RHOA GTPases in invasion, motility, and matrix adhesion in inflammatory and aggressive breast cancers." in: Cancer, Vol. 116, Issue 11 Suppl, pp. 2768-82, 2010 (PubMed).

Validation Images
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