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Mesothelin (MSLN) (AA 464-564) antibody

Details for Product No. ABIN394740
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Antigen
Synonyms MSLN, CEPR, CMKRL2, DRY12, FEG-1, GPCR-Br, GPER, GPR30, LERGU, LERGU2, LyGPR, 6330420K13Rik, Ceprl, Gper, Gpr30, MPF, SMRP
Epitope
AA 464-564
(13), (10), (5), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(82), (13), (6), (2), (1), (1)
Host
Mouse
(58), (29), (7), (3), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(52), (40), (20), (14), (12), (10), (8), (6), (6), (4), (4), (4), (4), (3)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394740
450.00 $
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Immunogen MSLN (NP_005814, 464 a.a. ~ 564 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1A10
Isotype IgG2b kappa
Specificity MSLN (NP_005814, 464 a.a. ~ 564 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MSLN
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 68986 DA
Gene ID 12406
UniProt NP_005814
Research Area Cell Structure, Cancer
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Mesothelin (MSLN) (AA 464-564) antibody Detection limit for recombinant GST tagged MSLN is approximately 1 ng/mL as a capture antibody.
Background publications Cristaudo, Foddis, Bonotti et al.: "Polymorphisms in the putative micro-RNA-binding sites of mesothelin gene are associated with serum levels of mesothelin-related protein." in: Occupational and environmental medicine, Vol. 67, Issue 4, pp. 233-6, 2010 (PubMed).

Rai, Flores, Mathew et al.: "Soluble mesothelin related peptides (SMRP) and osteopontin as protein biomarkers for malignant mesothelioma: analytical validation of ELISA based assays and characterization at mRNA and protein levels." in: Clinical chemistry and laboratory medicine : CCLM / FESCC, Vol. 48, Issue 2, pp. 271-8, 2010 (PubMed).

Obulhasim, Fujii, Matsumoto et al.: "Mesothelin gene expression and promoter methylation/hypomethylation in gynecological tumors." in: European journal of gynaecological oncology, Vol. 31, Issue 1, pp. 63-71, 2010 (PubMed).

Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

Tan, Kajino, Momose et al.: "Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter." in: Human pathology, Vol. 41, Issue 9, pp. 1330-8, 2010 (PubMed).

Validation Images
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