|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Mesothelin (MSLN) antibody
|Synonyms||MPF, SMR, CAK1, MSLN|
Alternatives ELISA, Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||MSLN (NP_005814, 464 a.a. ~ 564 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: CAK1, MPF, SMR mesothelin|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||MSLN (NP_005814, 464 a.a. ~ 564 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||68986 DA|
Background: This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.Preca|
|Research Area||Cell Structure, Cancer|
|Restrictions||For Research Use only|
|Detection limit for recombinant GST tagged MSLN is approximately 1ng/ml as a capture antibody.|
Cristaudo, Foddis, Bonotti et al.: "Polymorphisms in the putative micro-RNA-binding sites of mesothelin gene are associated with serum levels of mesothelin-related protein." in: Occupational and environmental medicine, Vol. 67, Issue 4, pp. 233-6, 2010 (PubMed).
Rai, Flores, Mathew et al.: "Soluble mesothelin related peptides (SMRP) and osteopontin as protein biomarkers for malignant mesothelioma: analytical validation of ELISA based assays and characterization at mRNA and protein levels." in: Clinical chemistry and laboratory medicine : CCLM / FESCC, Vol. 48, Issue 2, pp. 271-8, 2010 (PubMed).
Obulhasim, Fujii, Matsumoto et al.: "Mesothelin gene expression and promoter methylation/hypomethylation in gynecological tumors." in: European journal of gynaecological oncology, Vol. 31, Issue 1, pp. 63-71, 2010 (PubMed).
Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).
Tan, Kajino, Momose et al.: "Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter." in: Human pathology, Vol. 41, Issue 9, pp. 1330-8, 2010 (PubMed).