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S100 Calcium Binding Protein A7 (S100A7) (AA 1-102) antibody

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Synonyms S100A7, PSOR1, S100A7c
AA 1-102
(32), (16), (15), (15), (11), (6), (3), (3), (2), (1)
(126), (9), (2), (1), (1)
(71), (41), (19), (3)
Clonality (Clone)
Monoclonal ()
(8), (7), (4), (4), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(103), (62), (36), (26), (13), (11), (6), (6), (5), (2), (2), (1)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen S100A7 (AAH34687, 1 a.a. ~ 102 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1A4
Isotype IgG1 kappa
Specificity S100A7 (AAH34687, 1 a.a. ~ 102 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name S100A7 (S100A7 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 11471 DA
Gene ID 12406
Research Area Cell Structure
Application Notes Western blot = 1:500-1000

Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-S100 Calcium Binding Protein A7 (S100A7) (AA 1-102) antibody (ABIN394768) Immunofluorescence of monoclonal antibody to S100A7 on A-431 cell (antibody concentra...
Immunohistochemistry (IHC) image for anti-S100 Calcium Binding Protein A7 (S100A7) (AA 1-102) antibody (ABIN394768) anti-S100 Calcium Binding Protein A7 (S100A7) (AA 1-102) antibody (Image 2)
Background publications Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Tieu, Peters, Carter et al.: "Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis." in: The Journal of allergy and clinical immunology, Vol. 125, Issue 3, pp. 667-75, 2010 (PubMed).

West, Watson: "S100A7 (psoriasin) is induced by the proinflammatory cytokines oncostatin-M and interleukin-6 in human breast cancer." in: Oncogene, Vol. 29, Issue 14, pp. 2083-92, 2010 (PubMed).

West, Farnell, Murray et al.: "Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding." in: Protein science : a publication of the Protein Society, Vol. 18, Issue 12, pp. 2615-23, 2009 (PubMed).

León, Murray, Cragg et al.: "Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways." in: Biochemistry, Vol. 48, Issue 44, pp. 10591-600, 2009 (PubMed).

Catalog No. ABIN394768
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