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S100 Calcium Binding Protein A7 (S100A7) antibody
|Synonyms||PSOR1, S100A7c, S100A7|
Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
|5 references available|
|Quantity||0.1mg (1 mg/ml)|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||S100A7 (AAH34687, 1 a.a. ~ 102 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: PSOR1, S100A7cS100 calcium binding protein A7 (psoriasin 1)|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||S100A7 (AAH34687, 1 a.a. ~ 102 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||11471 DA|
Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.Preca|
|Research Area||Cell Structure|
|Restrictions||For Research Use only|
León, Murray, Cragg et al.: "Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways." in: Biochemistry, Vol. 48, Issue 44, pp. 10591-600, 2009 (PubMed).
West, Farnell, Murray et al.: "Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding." in: Protein science : a publication of the Protein Society, Vol. 18, Issue 12, pp. 2615-23, 2009 (PubMed).
West, Watson: "S100A7 (psoriasin) is induced by the proinflammatory cytokines oncostatin-M and interleukin-6 in human breast cancer." in: Oncogene, Vol. 29, Issue 14, pp. 2083-92, 2010 (PubMed).
Tieu, Peters, Carter et al.: "Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis." in: The Journal of allergy and clinical immunology, Vol. 125, Issue 3, pp. 667-75, 2010 (PubMed).
Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).
|Hosts||Rabbit (46), Mouse (9), Goat (4), Sheep (3)|
|Reactivities||Human (42), Cow (Bovine) (18), Horse (Equine) (18), Mouse (Murine) (18), Rat (Rattus) (18)|
|Applications||Immunofluorescence (IF) (31), Western Blotting (WB) (26), ELISA (17), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (14), Immunohistochemistry (IHC) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Immunohistochemistry (Frozen Sections) (IHC (fro)) (4), Immunoprecipitation (IP) (4), Immunoelectron Microscopy (IEM) (2)|
|Conjugates||Biotin (3), Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), PE,Cy7 (2)|
|Epitopes||AA 1-50 (2), Internal Region (2), N-Term (1), N-Term,AA 1-31 (1)|