Prothrombin antibody (Coagulation Factor II (thrombin)) (AA 263-362)

Details for Product anti-F2 Antibody No. ABIN394859, Supplier: Log in to see
Antigen
  • zgc:66319
  • wu:fb57c10
  • wu:fd42e09
  • wu:fd59d01
  • Cf-2
  • Cf2
  • FII
  • thrombin
  • PT
  • RPRGL2
  • THPH1
  • prothrombin
  • AA959438
  • AI255193
  • AI327365
  • C1sa
  • HTRA
  • HTRA1
  • F2
  • coagulation factor II (thrombin)
  • cell division cycle 34
  • chymase 1, mast cell
  • coagulation factor II
  • complement component 1, s subcomponent
  • HtrA serine peptidase 1
  • HtrA serine peptidase 2
  • melanoma antigen family B, 17-like
  • prothrombin-like
  • serine protease
  • THROMBIN protein
  • f2
  • F2
  • Cdc34
  • CMA1
  • C1s
  • Htra1
  • HTRA2
  • LOC783975
  • LOC100856539
  • HTRA
  • THROMBIN
Alternatives
anti-Human Prothrombin antibody for Immunodiffusion
Epitope
AA 263-362
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3
2
2
2
2
2
2
2
1
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1
Reactivity
Human
149
69
36
8
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4
2
2
2
2
1
Host
Mouse
85
62
56
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2
Clonality (Clone)
Monoclonal ()
Conjugate
This Prothrombin antibody is un-conjugated
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12
12
5
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1
1
1
1
1
1
1
1
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1
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1
Application
Western Blotting (WB)
143
108
39
20
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16
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14
13
11
8
6
3
3
2
1
1
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen F2 (AAH51332, 263 a.a. ~ 362 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1B7
Isotype IgG Mix kappa
Specificity F2 (AAH51332, 263 a.a. ~ 362 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name F2 (F2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 70037 DA
Gene ID 12406
Research Area Cell Structure
Pathways Complement System, Peptide Hormone Metabolism, Regulation of G-Protein Coupled Receptor Protein Signaling
Application Notes Western blot = 1:500-1000
Comment

Background: Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Coagulation Factor II (thrombin) (F2) (AA 263-362) antibody (ABIN394859) Western Blot analysis of F2 expression in transfected 293T cell line by F2 monoclonal...
Immunohistochemistry (IHC) image for anti-Coagulation Factor II (thrombin) (F2) (AA 263-362) antibody (ABIN394859) anti-Coagulation Factor II (thrombin) (F2) (AA 263-362) antibody (Image 2)
Background publications Fusconi, Chistolini, Angelosanto, Pignoloni, Tombolini, De Virgilio, Pagliarella, de Vincentiis: "Role of genetic and acquired prothrombotic risk factors in genesis of sudden sensorineural hearing loss." in: Audiology & neuro-otology, Vol. 16, Issue 3, pp. 185-90, 2011 (PubMed).

Jacobsen, Dahm, Bergrem, Jacobsen, Sandset: "Risk of venous thrombosis in pregnancy among carriers of the factor V Leiden and the prothrombin gene G20210A polymorphisms." in: Journal of thrombosis and haemostasis : JTH, Vol. 8, Issue 11, pp. 2443-9, 2011 (PubMed).

Ikejiri, Wada, Sakamoto, Ito, Nishioka, Nakatani, Tsuji, Yamada, Nakamura, Ito, Nobori: "The association of protein S Tokushima-K196E with a risk of deep vein thrombosis." in: International journal of hematology, Vol. 92, Issue 2, pp. 302-5, 2010 (PubMed).

Evagelidou, Giapros, Challa, Cholevas, Vartholomatos, Siomou, Kolaitis, Bairaktari, Andronikou: "Prothrombotic state, cardiovascular, and metabolic syndrome risk factors in prepubertal children born large for gestational age." in: Diabetes Care, Vol. 33, Issue 11, pp. 2468-70, 2010 (PubMed).

Simchen, Ofir, Moran, Kedem, Sivan, Schiff: "Thrombophilic risk factors for placental stillbirth." in: European journal of obstetrics, gynecology, and reproductive biology, Vol. 153, Issue 2, pp. 160-4, 2010 (PubMed).

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