|+1 404 474 4654|
|+1 888 205 9894 (TF)|
N-Acetylglucosaminidase, alpha (NAGLU) antibody
|Synonyms||NAG, MPS3B, UFHSD, MPS-IIIB, NAGLU|
ELISA, Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||NAGLU (NP_000254, 644 a.a. ~ 743 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: NAG, UFHSD N-acetylglucosaminidase, alpha- (Sanfilippo disease IIIB)|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||NAGLU (NP_000254, 644 a.a. ~ 743 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||82167 DA|
Background: This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Cell Structure|
|Restrictions||For Research Use only|
|NAGLU monoclonal antibody (M02), clone 1B7. Western Blot analysis of NAGLU expression in Jurkat ( Cat # L017V1 ).|
Clark, Glanowski, Nielsen et al.: "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios." in: Science (New York, N.Y.), Vol. 302, Issue 5652, pp. 1960-3, 2003 (PubMed).
Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).
Chinen, Tohma, Izumikawa et al.: "Sanfilippo type B syndrome: five patients with an R565P homozygous mutation in the alpha-N-acetylglucosaminidase gene from the Okinawa islands in Japan." in: Journal of human genetics, Vol. 50, Issue 7, pp. 357-9, 2005 (PubMed).
Mangas, Nogueira, Prata et al.: "Molecular analysis of mucopolysaccharidosis type IIIB in Portugal: evidence of a single origin for a common mutation (R234C) in the Iberian Peninsula." in: Clinical genetics, Vol. 73, Issue 3, pp. 251-6, 2008 (PubMed).
Champion, Basehore, Wood et al.: "Identification and characterization of a novel homozygous deletion in the alpha-N-acetylglucosaminidase gene in a patient with Sanfilippo type B syndrome (mucopolysaccharidosis IIIB)." in: Molecular genetics and metabolism, Vol. 100, Issue 1, pp. 51-6, 2010 (PubMed).