N-Acetylglucosaminidase, alpha (NAGLU) antibody

Details for Product No. ABIN394860
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Antigen
Synonyms NAG, MPS3B, UFHSD, MPS-IIIB
Reactivity
Human
(7), (4), (3)
Host
Mouse
(9), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2)
Application
Western Blotting (WB)
(13), (9), (7), (4), (4), (3), (2), (2)
Pubmed 5 references available
Catalog no. ABIN394860
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen NAGLU (NP_000254, 644 a.a. ~ 743 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1B7
Isotype IgG2a kappa
Specificity NAGLU (NP_000254, 644 a.a. ~ 743 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name NAGLU
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 82167 DA
Gene ID 12406
UniProt NP_000254
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-N-Acetylglucosaminidase, alpha (NAGLU) antibody NAGLU monoclonal antibody (M02), clone 1B7. Western Blot analysis of NAGLU expression in Jurkat.
Background publications Clark, Glanowski, Nielsen et al.: "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios." in: Science (New York, N.Y.), Vol. 302, Issue 5652, pp. 1960-3, 2003 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Chinen, Tohma, Izumikawa et al.: "Sanfilippo type B syndrome: five patients with an R565P homozygous mutation in the alpha-N-acetylglucosaminidase gene from the Okinawa islands in Japan." in: Journal of human genetics, Vol. 50, Issue 7, pp. 357-9, 2005 (PubMed).

Mangas, Nogueira, Prata et al.: "Molecular analysis of mucopolysaccharidosis type IIIB in Portugal: evidence of a single origin for a common mutation (R234C) in the Iberian Peninsula." in: Clinical genetics, Vol. 73, Issue 3, pp. 251-6, 2008 (PubMed).

Champion, Basehore, Wood et al.: "Identification and characterization of a novel homozygous deletion in the alpha-N-acetylglucosaminidase gene in a patient with Sanfilippo type B syndrome (mucopolysaccharidosis IIIB)." in: Molecular genetics and metabolism, Vol. 100, Issue 1, pp. 51-6, 2010 (PubMed).

Hosts (9), (4)
Reactivities (7), (4), (3)
Applications (13), (9), (7), (4), (4), (3), (2), (2)
Conjugates (2), (2)
Epitopes (2), (1), (1)
back to top