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Details for Product No. ABIN394877

Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3) antibody

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Antigen
Synonyms KV3.3, SCA13, KSHIIID, kcnc1, kshiiid, kv3.3, sca13, KShIIID, Kcr2-3, Kv3.3, kcnc3-A, Kv3.1
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN394877
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen KCNC3 (NP_004968, 671 a.a. ~ 758 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1C1
Isotype IgG1 kappa
Specificity KCNC3 (NP_004968, 671 a.a. ~ 758 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name KCNC3
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 80520 DA
Gene ID 12406
UniProt NP_004968
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence
Comment

Background: The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Brusco, Gellera, Cagnoli et al.: "Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families." in: Archives of neurology, Vol. 61, Issue 5, pp. 727-33, 2004 (PubMed).

Gutman, Chandy, Grissmer et al.: "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 473-508, 2005 (PubMed).

Waters, Minassian, Stevanin et al.: "Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes." in: Nature genetics, Vol. 38, Issue 4, pp. 447-51, 2006 (PubMed).

Waters, Pulst: "Sca13." in: Cerebellum (London, England), Vol. 7, Issue 2, pp. 165-9, 2008 (PubMed).

Figueroa, Minassian, Stevanin et al.: "KCNC3: phenotype, mutations, channel biophysics-a study of 260 familial ataxia patients." in: Human mutation, Vol. 31, Issue 2, pp. 191-6, 2010 (PubMed).

Alternatives for antigen "Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3)", type "Antibodies"
Hosts (29), (12), (5)
Reactivities (39), (20), (17), (13), (12), (12), (2), (1), (1)
Applications (37), (27), (10), (7), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (6), (5), (4), (2), (2), (1), (1), (1), (1)
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