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S100 Calcium Binding Protein A7 (S100A7) (AA 1-102) antibody

Details for Product No. ABIN394880, Supplier: Login to see
Antigen
  • S100A7
  • PSOR1
  • S100A7c
Epitope
AA 1-102
32
16
15
15
11
5
3
3
2
1
Reactivity
Human
124
8
2
1
1
Host
Mouse
68
41
19
3
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
7
7
4
4
3
3
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
100
59
35
24
13
11
6
4
3
2
2
1
Supplier
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Immunogen S100A7 (AAH34687, 1 a.a. ~ 102 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1C1
Isotype IgG2a kappa
Specificity S100A7 (AAH34687, 1 a.a. ~ 102 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name S100A7 (S100A7 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 11471 DA
Gene ID 12406
Research Area Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-S100 Calcium Binding Protein A7 (S100A7) (AA 1-102) antibody (ABIN394880) Immunofluorescence of monoclonal antibody to S100A7 on A-431 cell (antibody concentra...
Immunohistochemistry (IHC) image for anti-S100 Calcium Binding Protein A7 (S100A7) (AA 1-102) antibody (ABIN394880) anti-S100 Calcium Binding Protein A7 (S100A7) (AA 1-102) antibody (Image 2)
Background publications Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Tieu, Peters, Carter et al.: "Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis." in: The Journal of allergy and clinical immunology, Vol. 125, Issue 3, pp. 667-75, 2010 (PubMed).

West, Watson: "S100A7 (psoriasin) is induced by the proinflammatory cytokines oncostatin-M and interleukin-6 in human breast cancer." in: Oncogene, Vol. 29, Issue 14, pp. 2083-92, 2010 (PubMed).

West, Farnell, Murray et al.: "Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding." in: Protein science : a publication of the Protein Society, Vol. 18, Issue 12, pp. 2615-23, 2009 (PubMed).

León, Murray, Cragg et al.: "Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways." in: Biochemistry, Vol. 48, Issue 44, pp. 10591-600, 2009 (PubMed).