S100 Calcium Binding Protein A7 (S100A7) antibody

Antigen: S100 Calcium Binding Protein A7 (S100A7)

Synonyms: PSOR1, S100A7c, S100A7

Clonality: Monoclonal (1C1)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Immunofluorescence (IF), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN394880

Additional Information

Alternative name: S100A7

Gene ID: 6278

Immunogen: S100A7 (AAH34687, 1 a.a. ~ 102 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 1C1

Description: Other names: PSOR1, S100A7c S100 calcium binding protein A7 (psoriasin 1)

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: S100A7 (AAH34687, 1 a.a. ~ 102 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 11471 DA

Comments:

Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.Preca

Research Area: Cell Structure

Restrictions: For Research Use only

Images

Immunofluorescence of monoclonal antibody to S100A7 (AT3762a) on A-431 cell . [antibody concentration 10 ug/ml] S100A7 monoclonal antibody (M03), clone 1C1 Western Blot analysis of S100A7 expression in A-431 ( Cat # L015V1 ).

anti-S100 Calcium Binding Protein A7 (S100A7) antibody (Image 2)

Publications

Product: León, Murray, Cragg et al.: "Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways." in: Biochemistry, Vol. 48, Issue 44, pp. 10591-600, 2009 (PubMed).

West, Farnell, Murray et al.: "Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding." in: Protein science : a publication of the Protein Society, Vol. 18, Issue 12, pp. 2615-23, 2009 (PubMed).

West, Watson: "S100A7 (psoriasin) is induced by the proinflammatory cytokines oncostatin-M and interleukin-6 in human breast cancer." in: Oncogene, Vol. 29, Issue 14, pp. 2083-92, 2010 (PubMed).

Tieu, Peters, Carter et al.: "Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis." in: The Journal of allergy and clinical immunology, Vol. 125, Issue 3, pp. 667-75, 2010 (PubMed).

Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).