anti-SKAP1 antibody (Src Kinase Associated phosphoprotein 1) (AA 1-101)

Details for Product anti-SKAP1 Antibody No. ABIN394892
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Synonyms 1700091G21Rik, Scap1, Skap-55, SCAP1, SKAP55, Skap55
AA 1-101
(15), (14), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
(57), (17), (4)
(49), (7), (1)
Clonality (Clone)
Monoclonal ()
This SKAP1 antibody is un-conjugated
(5), (5), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(43), (26), (10), (7), (3), (3), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen SCAP1 (NP_003717, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1C11
Isotype IgG1 kappa
Specificity SCAP1 (NP_003717, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SCAP1 (SKAP1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 41462 DA
Gene ID 12406
NCBI Accession NP_003717
Research Area Cell Signaling, Cell Structure
Pathways TCR Signaling
Application Notes Western blot = 1:500-1000

Background: This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-SKAP1 antibody (Src Kinase Associated phosphoprotein 1) (AA 1-101) (ABIN394892) SCAP1 monoclonal antibody (M02), clone 1C11 Western Blot analysis of SCAP1 expression...
Immunohistochemistry (IHC) image for anti-SKAP1 antibody (Src Kinase Associated phosphoprotein 1) (AA 1-101) (ABIN394892) anti-Src Kinase Associated phosphoprotein 1 (SKAP1) (AA 1-101) antibody (Image 2)
Background publications Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Raab, Wang, Lu et al.: "T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes." in: Immunity, Vol. 32, Issue 4, pp. 541-56, 2010 (PubMed).

Lehmann, Meyer, Schuemann et al.: "A novel S3S-TAP-tag for the isolation of T-cell interaction partners of adhesion and degranulation promoting adaptor protein." in: Proteomics, Vol. 9, Issue 23, pp. 5288-95, 2009 (PubMed).

Fang, Seki, Fang: "SKAP associates with kinetochores and promotes the metaphase-to-anaphase transition." in: Cell cycle (Georgetown, Tex.), Vol. 8, Issue 17, pp. 2819-27, 2009 (PubMed).

Kosco, Cerignoli, Williams et al.: "SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1." in: Molecular immunology, Vol. 45, Issue 2, pp. 510-22, 2007 (PubMed).

Catalog No. ABIN394892
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