Src Kinase Associated phosphoprotein 1 (SKAP1) (AA 1-101) antibody

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Antigen
Synonyms 1700091G21Rik, Scap1, Skap-55, SCAP1, SKAP55, Skap55
Epitope
AA 1-101
(15), (14), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(58), (16), (4)
Host
Mouse
(49), (8), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(43), (27), (10), (8), (3), (3), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Immunogen SCAP1 (NP_003717, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1C11
Isotype IgG1 kappa
Specificity SCAP1 (NP_003717, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SCAP1 (SKAP1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 41462 DA
Gene ID 12406
NCBI Accession NP_003717
Research Area Cell Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Src Kinase Associated phosphoprotein 1 (SKAP1) (AA 1-101) antibody SCAP1 monoclonal antibody (M02), clone 1C11 Western Blot analysis of SCAP1 expression...
anti-Src Kinase Associated phosphoprotein 1 (SKAP1) (AA 1-101) antibody (2) anti-Src Kinase Associated phosphoprotein 1 (SKAP1) (AA 1-101) antibody (Image 2)
Background publications Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Raab, Wang, Lu et al.: "T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes." in: Immunity, Vol. 32, Issue 4, pp. 541-56, 2010 (PubMed).

Lehmann, Meyer, Schuemann et al.: "A novel S3S-TAP-tag for the isolation of T-cell interaction partners of adhesion and degranulation promoting adaptor protein." in: Proteomics, Vol. 9, Issue 23, pp. 5288-95, 2009 (PubMed).

Fang, Seki, Fang: "SKAP associates with kinetochores and promotes the metaphase-to-anaphase transition." in: Cell cycle (Georgetown, Tex.), Vol. 8, Issue 17, pp. 2819-27, 2009 (PubMed).

Kosco, Cerignoli, Williams et al.: "SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1." in: Molecular immunology, Vol. 45, Issue 2, pp. 510-22, 2007 (PubMed).

Validation Images
Catalog No. ABIN394892
450.00 $
Plus shipping costs $45.00
Quantity
Price
0.1 mg
450.00 $

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