Src Kinase Associated phosphoprotein 1 (SKAP1) antibody

Details for Product No. ABIN394892
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Synonyms SCAP1, SKAP55, 1700091G21Rik, Scap1, Skap-55, Skap55
(29), (16), (4)
(24), (5), (1)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(21), (11), (10), (6), (2), (1), (1)
Pubmed 5 references available
Catalog no. ABIN394892
Quantity 0.1 mg
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Immunogen SCAP1 (NP_003717, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1C11
Isotype IgG1 kappa
Specificity SCAP1 (NP_003717, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SCAP1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 41462 DA
Gene ID 12406
UniProt NP_003717
Research Area Cell Signaling, Cell Structure
Application Notes Western blot = 1:500-1000

Background: This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Src Kinase Associated phosphoprotein 1 (SKAP1) antibody SCAP1 monoclonal antibody (M02), clone 1C11 Western Blot analysis of SCAP1 expression in Jurkat. Detection limit for recombinant GST tagged SCAP1 is approximately 0.3 ng/mL as a capture antibody.
anti-Src Kinase Associated phosphoprotein 1 (SKAP1) antibody (2) anti-Src Kinase Associated phosphoprotein 1 (SKAP1) antibody (Image 2)
Background publications Kosco, Cerignoli, Williams et al.: "SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1." in: Molecular immunology, Vol. 45, Issue 2, pp. 510-22, 2007 (PubMed).

Fang, Seki, Fang: "SKAP associates with kinetochores and promotes the metaphase-to-anaphase transition." in: Cell cycle (Georgetown, Tex.), Vol. 8, Issue 17, pp. 2819-27, 2009 (PubMed).

Lehmann, Meyer, Schuemann et al.: "A novel S3S-TAP-tag for the isolation of T-cell interaction partners of adhesion and degranulation promoting adaptor protein." in: Proteomics, Vol. 9, Issue 23, pp. 5288-95, 2009 (PubMed).

Raab, Wang, Lu et al.: "T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes." in: Immunity, Vol. 32, Issue 4, pp. 541-56, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Hosts (24), (5), (1)
Reactivities (29), (16), (4)
Applications (21), (11), (10), (6), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (2), (2), (2), (1), (1)
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