ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) antibody

Details for Product No. ABIN394929
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Antigen
Synonyms ABC30, CMOAT, DJS, MRP2, cMRP, AI173996, Abc30, Cmoat, Mrp2
Reactivity
Human
(46), (7), (3)
Host
Mouse
(30), (20)
Clonality (Clone)
Monoclonal ()
Application
ELISA, Western Blotting (WB)
(49), (22), (19), (16), (15), (13), (11), (5), (1)
Pubmed 5 references available
Catalog no. ABIN394929
Quantity 0.05 mg
Price
450.00 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen ABCC2 (NP_000383, 214 a.a. ~ 314 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1C5
Isotype IgG1 kappa
Specificity ABCC2 (NP_000383, 214 a.a. ~ 314 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name ABCC2
Background The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine, therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
Synonyms: ABC30, CMOAT, DJS, KIAA1010, MRP2, cMRP ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Molecular Weight 174191 DA
Gene ID 1244
UniProt NP_000383
Research Area Cell Structure, Cancer
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine, therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

Restrictions For Research Use only
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) antibody Detection limit for recombinant GST tagged ABCC2 is approximately 0.03 ng/mL as a capture antibody.
Background publications Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

McLeod, Sargent, Marsh et al.: "Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 28, Issue 20, pp. 3227-33, 2010 (PubMed).

Woillard, Rerolle, Picard et al.: "Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant allele." in: British journal of clinical pharmacology, Vol. 69, Issue 6, pp. 675-83, 2010 (PubMed).

Hu, Lui, Mak et al.: "Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients." in: Pharmacogenetics and genomics, Vol. 20, Issue 10, pp. 634-7, 2010 (PubMed).

Takahashi, Miura, Scott et al.: "Influence of CYP3A5 and drug transporter polymorphisms on imatinib trough concentration and clinical response among patients with chronic phase chronic myeloid leukemia." in: Journal of human genetics, Vol. 55, Issue 11, pp. 731-7, 2010 (PubMed).

Hosts (30), (20)
Reactivities (46), (7), (3)
Applications (49), (22), (19), (16), (15), (13), (11), (5), (1)
Epitopes (9), (4), (2), (2), (2), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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