Scavenger Receptor Class B, Member 2 (SCARB2) antibody

Details for Product No. ABIN394954
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Synonyms AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII, Cd36l2, MLGP85, 9330185J12Rik, LimpII, cd36l2, fi13c07, chunp6914, wu:fi13c07, SCARB2, scarb2
(42), (24), (13), (4), (3), (1), (1), (1)
(38), (6), (4)
Clonality (Clone)
Monoclonal ()
(45), (26), (17), (14), (8), (6), (3), (1), (1)
Pubmed 5 references available
Catalog no. ABIN394954
Quantity 0.1 mg
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Immunogen SCARB2 (NP_005497, 339 a.a. ~ 438 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1C8
Isotype IgG2a kappa
Specificity SCARB2 (NP_005497, 339 a.a. ~ 438 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SCARB2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 54290 DA
Gene ID 12406
UniProt NP_005497
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml

Background: The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Studies of the similar protein in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. Deficiency of the similar protein in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Scavenger Receptor Class B, Member 2 (SCARB2) antibody Detection limit for recombinant GST tagged SCARB2 is approximately 0.1 ng/mL as a capture antibody.
Background publications Blanz, Groth, Zachos et al.: "Disease-causing mutations within the lysosomal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand beta-glucocerebrosidase." in: Human molecular genetics, Vol. 19, Issue 4, pp. 563-72, 2010 (PubMed).

Ishikawa, Kimura-Matsumoto, Murakami et al.: "Distribution of smooth muscle cells and macrophages expressing scavenger receptor BI/II in atherosclerosis." in: Journal of atherosclerosis and thrombosis, Vol. 16, Issue 6, pp. 829-39, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Hosts (38), (6), (4)
Reactivities (42), (24), (13), (4), (3), (1), (1), (1)
Applications (45), (26), (17), (14), (8), (6), (3), (1), (1)
Epitopes (12), (6), (4), (2), (2), (2), (1), (1)
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