Scavenger Receptor Class B, Member 2 (SCARB2) antibody

Antigen: Scavenger Receptor Class B, Member 2 (SCARB2)

Synonyms: AMRF, CD36L2, HLGP85, LIMPII, SR-BII, LGP85, Cd36l2, LIMP-2, MLGP85, 9330185J12Rik, LimpII, cd36l2, fi13c07, chunp6914, wu:fi13c07, SCARB2, scarb2, MGC140207

Clonality: Monoclonal (1C8)

Host: Mouse

Reactivity: Human

Application: ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN394954

Additional Information

Alternative name: SCARB2

Gene ID: 950

UniProt: NP_005497

Immunogen: SCARB2 (NP_005497, 339 a.a. ~ 438 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 1C8

Description: Other names: CD36L2, HLGP85, LIMPII, SRBII scavenger receptor class B, member 2

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: SCARB2 (NP_005497, 339 a.a. ~ 438 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 54290 DA

Comments:

Background: The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Studies of the similar protein in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. Deficiency of the similar protein in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged SCARB2 is approximately 0.1ng/ml as a capture antibody.

Publications

Product: Blanz, Groth, Zachos et al.: "Disease-causing mutations within the lysosomal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand beta-glucocerebrosidase." in: Human molecular genetics, Vol. 19, Issue 4, pp. 563-72, 2010 (PubMed).

Ishikawa, Kimura-Matsumoto, Murakami et al.: "Distribution of smooth muscle cells and macrophages expressing scavenger receptor BI/II in atherosclerosis." in: Journal of atherosclerosis and thrombosis, Vol. 16, Issue 6, pp. 829-39, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).