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EBI3 antibody (Epstein-Barr Virus Induced 3) (AA 129-230)

Details for Product anti-EBI3 Antibody No. ABIN394997, Supplier: Log in to see
Antigen
  • IL-27B
  • IL27B
  • EBI-3
  • IL-27
Epitope
AA 129-230
21
15
10
9
6
4
4
3
2
2
2
2
1
1
1
1
1
Reactivity
Human
92
48
21
1
1
1
1
1
1
Host
Mouse
85
13
8
7
Clonality (Clone)
Monoclonal ()
Conjugate
This EBI3 antibody is un-conjugated
6
6
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
ELISA
88
56
22
19
11
7
5
4
3
2
1
Supplier
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Immunogen EBI3 (NP_005746, 129 a.a. ~ 230 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D3
Isotype IgG2a kappa
Specificity EBI3 (NP_005746, 129 a.a. ~ 230 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name EBI3 (EBI3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 25396 DA
Gene ID 12406
NCBI Accession NP_005746
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-EBI3 antibody (Epstein-Barr Virus Induced 3) (AA 129-230) (ABIN394997) Detection limit for recombinant GST tagged EBI3 is approximately 0.3 ng/mL as a captu...
Background publications Kempe, Heinz, Kokai et al.: "Epstein-barr virus-induced gene-3 is expressed in human atheroma plaques." in: The American journal of pathology, Vol. 175, Issue 1, pp. 440-7, 2009 (PubMed).

Carl, Bai: "IL27: its roles in the induction and inhibition of inflammation." in: International journal of clinical and experimental pathology, Vol. 1, Issue 2, pp. 117-23, 2008 (PubMed).

Poleganov, Bachmann, Pfeilschifter et al.: "Genome-wide analysis displays marked induction of EBI3/IL-27B in IL-18-activated AML-derived KG1 cells: critical role of two kappaB binding sites in the human EBI3 promotor." in: Molecular immunology, Vol. 45, Issue 10, pp. 2869-80, 2008 (PubMed).

Krumbiegel, Anthogalidis-Voss, Markus et al.: "Enhanced expression of IL-27 mRNA in human newborns." in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, Vol. 19, Issue 6, pp. 513-6, 2008 (PubMed).

Rual, Venkatesan, Hao et al.: "Towards a proteome-scale map of the human protein-protein interaction network. ..." in: Nature, Vol. 437, Issue 7062, pp. 1173-8, 2005 (PubMed).