Epstein-Barr Virus Induced 3 (EBI3) (AA 129-230) antibody

Details for Product No. ABIN394997
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Antigen
Synonyms IL-27B, IL27B, EBI-3, IL-27
Epitope
AA 129-230
(13), (6), (6), (6), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(67), (62), (25), (12), (12), (12), (1)
Host
Mouse
(64), (20), (14), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(13), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA
(83), (59), (20), (16), (15), (12), (10), (10), (4), (3), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394997
450.00 $
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Immunogen EBI3 (NP_005746, 129 a.a. ~ 230 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D3
Isotype IgG2a kappa
Specificity EBI3 (NP_005746, 129 a.a. ~ 230 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name EBI3
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 25396 DA
Gene ID 12406
NCBI Accession NP_005746
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Epstein-Barr Virus Induced 3 (EBI3) (AA 129-230) antibody Detection limit for recombinant GST tagged EBI3 is approximately 0.3 ng/mL as a capture antibody.
Background publications Rual, Venkatesan, Hao et al.: "Towards a proteome-scale map of the human protein-protein interaction network." in: Nature, Vol. 437, Issue 7062, pp. 1173-8, 2005 (PubMed).

Krumbiegel, Anthogalidis-Voss, Markus et al.: "Enhanced expression of IL-27 mRNA in human newborns." in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, Vol. 19, Issue 6, pp. 513-6, 2008 (PubMed).

Poleganov, Bachmann, Pfeilschifter et al.: "Genome-wide analysis displays marked induction of EBI3/IL-27B in IL-18-activated AML-derived KG1 cells: critical role of two kappaB binding sites in the human EBI3 promotor." in: Molecular immunology, Vol. 45, Issue 10, pp. 2869-80, 2008 (PubMed).

Carl, Bai: "IL27: its roles in the induction and inhibition of inflammation." in: International journal of clinical and experimental pathology, Vol. 1, Issue 2, pp. 117-23, 2008 (PubMed).

Kempe, Heinz, Kokai et al.: "Epstein-barr virus-induced gene-3 is expressed in human atheroma plaques." in: The American journal of pathology, Vol. 175, Issue 1, pp. 440-7, 2009 (PubMed).

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