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AMACR antibody (alpha-Methylacyl-CoA Racemase) (AA 1-199)

Details for Product anti-AMACR Antibody No. ABIN395030, Supplier: Login to see
Antigen
  • AMACR
  • DKFZp469O1232
  • amacr
  • NCU04099.1
  • MGC89832
  • AMACRD
  • CBAS4
  • RACE
  • RM
  • Macr1
  • Da1-8
  • Marc1
Epitope
AA 1-199
29
10
9
5
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
159
35
34
Host
Mouse
112
45
2
Clonality (Clone)
Monoclonal ()
Conjugate
This AMACR antibody is un-conjugated
6
5
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
113
77
55
34
24
20
15
11
10
6
4
4
2
2
1
Supplier
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Immunogen AMACR (AAH09471, 1 a.a. ~ 199 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D8
Isotype IgG2b kappa
Specificity AMACR (AAH09471, 1 a.a. ~ 199 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name AMACR (AMACR Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 42360 DA
Gene ID 12406
Research Area Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-AMACR antibody (alpha-Methylacyl-CoA Racemase) (AA 1-199) (ABIN395030) AMACR monoclonal antibody (M02), clone 1D8. Western Blot analysis of AMACR expression...
Background publications Lakis, Papamitsou, Panagiotopoulou et al.: "AMACR is associated with advanced pathologic risk factors in sporadic colorectal adenomas." in: World journal of gastroenterology : WJG, Vol. 16, Issue 20, pp. 2476-83, 2010 (PubMed).

Szponar, Beothe, Kovacs: "How useful is alpha-methylacyl-CoA racemase (AMACR) immunohistochemistry in the differential diagnosis of kidney cancers?" in: Histopathology, Vol. 56, Issue 2, pp. 263-5, 2010 (PubMed).

Guey, García-Closas, Murta-Nascimento et al.: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, 2010 (PubMed).

Halsey, Calder, Mathew et al.: "Expression of alpha-methylacyl-CoA racemase (P504S) in sebaceous neoplasms." in: Journal of cutaneous pathology, Vol. 37, Issue 4, pp. 446-51, 2010 (PubMed).

Hosgood, Menashe, He et al.: "PTEN identified as important risk factor of chronic obstructive pulmonary disease." in: Respiratory medicine, Vol. 103, Issue 12, pp. 1866-70, 2009 (PubMed).