alpha-Methylacyl-CoA Racemase (AMACR) antibody

Details for Product No. ABIN395030
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Antigen
Synonyms AMACRD, CBAS4, RACE, RM, Macr1, Da1-8, Marc1, AMACR, DKFZp469O1232, amacr, NCU04099.1, MGC89832
Reactivity
Human
(89), (27), (24)
Host
Mouse
(70), (19)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(51), (33), (29), (22), (10), (9), (9), (8), (3), (3), (2), (2), (2), (1)
Pubmed 5 references available
Catalog no. ABIN395030
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen AMACR (AAH09471, 1 a.a. ~ 199 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D8
Isotype IgG2b kappa
Specificity AMACR (AAH09471, 1 a.a. ~ 199 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name AMACR
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 42360 DA
Gene ID 12406
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-alpha-Methylacyl-CoA Racemase (AMACR) antibody AMACR monoclonal antibody (M02), clone 1D8. Western Blot analysis of AMACR expression in HepG2.
Background publications Hosgood, Menashe, He et al.: "PTEN identified as important risk factor of chronic obstructive pulmonary disease." in: Respiratory medicine, Vol. 103, Issue 12, pp. 1866-70, 2009 (PubMed).

Halsey, Calder, Mathew et al.: "Expression of alpha-methylacyl-CoA racemase (P504S) in sebaceous neoplasms." in: Journal of cutaneous pathology, Vol. 37, Issue 4, pp. 446-51, 2010 (PubMed).

Guey, García-Closas, Murta-Nascimento et al.: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, 2010 (PubMed).

Szponar, Beothe, Kovacs: "How useful is alpha-methylacyl-CoA racemase (AMACR) immunohistochemistry in the differential diagnosis of kidney cancers?" in: Histopathology, Vol. 56, Issue 2, pp. 263-5, 2010 (PubMed).

Lakis, Papamitsou, Panagiotopoulou et al.: "AMACR is associated with advanced pathologic risk factors in sporadic colorectal adenomas." in: World journal of gastroenterology : WJG, Vol. 16, Issue 20, pp. 2476-83, 2010 (PubMed).

Hosts (70), (19)
Reactivities (89), (27), (24)
Applications (51), (33), (29), (22), (10), (9), (9), (8), (3), (3), (2), (2), (2), (1)
Conjugates (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (3), (2), (2), (1), (1), (1), (1)
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