|+1 404 474 4654|
|+1 888 205 9894 (TF)|
alpha-Methylacyl-CoA Racemase (AMACR) antibody
|Synonyms||RACE, CBAS4, Macr1, Da1-8, Marc1, AMACR, DKFZp469O1232, amacr, MGC89832|
Alternatives ELISA, Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||AMACR (AAH09471, 1 a.a. ~ 199 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: RACE alpha-methylacyl-CoA racemase|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||AMACR (AAH09471, 1 a.a. ~ 199 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||42360 DA|
Background: This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.Preca|
|Research Area||Cell Structure|
|Restrictions||For Research Use only|
|AMACR monoclonal antibody (M02), clone 1D8. Western Blot analysis of AMACR expression in HepG2 ( Cat # L019V1 ).|
Hosgood, Menashe, He et al.: "PTEN identified as important risk factor of chronic obstructive pulmonary disease." in: Respiratory medicine, Vol. 103, Issue 12, pp. 1866-70, 2009 (PubMed).
Halsey, Calder, Mathew et al.: "Expression of alpha-methylacyl-CoA racemase (P504S) in sebaceous neoplasms." in: Journal of cutaneous pathology, Vol. 37, Issue 4, pp. 446-51, 2010 (PubMed).
Guey, García-Closas, Murta-Nascimento et al.: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, 2010 (PubMed).
Szponar, Beothe, Kovacs: "How useful is alpha-methylacyl-CoA racemase (AMACR) immunohistochemistry in the differential diagnosis of kidney cancers?" in: Histopathology, Vol. 56, Issue 2, pp. 263-5, 2010 (PubMed).
Lakis, Papamitsou, Panagiotopoulou et al.: "AMACR is associated with advanced pathologic risk factors in sporadic colorectal adenomas." in: World journal of gastroenterology : WJG, Vol. 16, Issue 20, pp. 2476-83, 2010 (PubMed).
|Hosts||Rabbit (33), Mouse (10)|
|Reactivities||Human (42), Rat (Rattus) (3), Mouse (Murine) (2)|
|Applications||Western Blotting (WB) (21), Immunohistochemistry (IHC) (18), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (18), ELISA (11), Immunohistochemistry (Frozen Sections) (IHC (fro)) (5), Immunofluorescence (IF) (3), Flow Cytometry (FACS) (1)|
|Epitopes||C-Term (3), C-Term,AA 330-359 (1), Internal Region (1), Middle Region (1)|