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Details for Product No. ABIN395038

Adrenocortical Dysplasia Homolog (Mouse) (ACD) antibody

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Antigen
Synonyms PIP1, PTOP, TPP1, TINT1, ACD
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN395038
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen ACD (AAH16904, 1 a.a. ~ 545 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D8-1B6
Isotype IgG1 kappa
Specificity ACD (AAH16904, 1 a.a. ~ 545 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ACD
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 57758 DA
Gene ID 12406
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml Immunofluorescence
Comment

Background: This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Else, Theisen, Wu et al.: "Tpp1/Acd maintains genomic stability through a complex role in telomere protection." in: Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, Vol. 15, Issue 8, pp. 1001-13, 2008 (PubMed).

Tang, Zhou, Lei et al.: "Increased expression of telomere-related proteins correlates with resistance to radiation in human laryngeal cancer cell lines." in: Oncology reports, Vol. 21, Issue 6, pp. 1505-9, 2009 (PubMed).

Wan, Qin, Songyang et al.: "OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation." in: The Journal of biological chemistry, Vol. 284, Issue 39, pp. 26725-31, 2009 (PubMed).

Varadi, Brendle, Brandt et al.: "Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis." in: European journal of cancer (Oxford, England : 1990), Vol. 45, Issue 17, pp. 3008-16, 2009 (PubMed).

Abreu, Aritonovska, Reichenbach et al.: "TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo." in: Molecular and cellular biology, Vol. 30, Issue 12, pp. 2971-82, 2010 (PubMed).

Alternatives for antigen "Adrenocortical Dysplasia Homolog (Mouse) (ACD)", type "Antibodies"
Hosts (38), (8)
Reactivities (40), (28), (24), (23), (23), (11)
Applications (27), (19), (13), (9), (5), (2), (2), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (5), (4), (2), (1), (1)
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