Glucagon (GCG) (AA 1-181) antibody

Details for Product No. ABIN395053
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Antigen
Synonyms GCG, 9230102N17Rik, D330003E03, Eu-HMTase1, GLP, GLP1, KMT1D, mKIAA1876, EUHMTASE1, FP13812, bA188C12.1, GLP2, GRPP, GLP-1, Glu, PPG, gcg-A, gcg1, 9530092J08Rik, GLP-2, GATAD3
Epitope
AA 1-181
(21), (18), (15), (7), (7), (7), (6), (6), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(316), (136), (116), (49), (44), (40), (13), (12), (6), (4), (1), (1), (1), (1)
Host
Mouse
(232), (103), (18), (6), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(24), (11), (10), (9), (8), (8), (8), (8), (8), (8), (8), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(138), (120), (98), (80), (39), (31), (26), (24), (22), (15), (14), (13), (10), (6), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN395053
450.00 $
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Immunogen GCG (AAH05278, 1 a.a. ~ 181 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1E2-E6
Isotype IgG1 kappa
Specificity GCG (AAH05278, 1 a.a. ~ 181 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GCG
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 20909 DA
Gene ID 12406
Research Area Cell Cycle, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Glucagon (GCG) (AA 1-181) antibody Detection limit for recombinant GST tagged GCG is approximately 0.1 ng/mL as a capture antibody.
Background publications Valsamakis, Margeli, Vitoratos et al.: "The role of maternal gut hormones in normal pregnancy: fasting plasma active glucagon-like peptide 1 level is a negative predictor of fetal abdomen circumference and maternal weight change." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 162, Issue 5, pp. 897-903, 2010 (PubMed).

Brubaker: "Minireview: update on incretin biology: focus on glucagon-like peptide-1." in: Endocrinology, Vol. 151, Issue 5, pp. 1984-9, 2010 (PubMed).

Yamaoka-Tojo, Tojo, Takahira et al.: "Elevated circulating levels of an incretin hormone, glucagon-like peptide-1, are associated with metabolic components in high-risk patients with cardiovascular disease." in: Cardiovascular diabetology, Vol. 9, pp. 17, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Jablonski, McAteer, de Bakker et al.: "Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program." in: Diabetes, Vol. 59, Issue 10, pp. 2672-81, 2010 (PubMed).

Validation Images
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