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RAS P21 Protein Activator 3 (RASA3) (AA 725-834) antibody

Details for Product No. ABIN395074, Supplier: Login to see
Antigen
  • rasa3
  • MGC82492
  • RASA3
  • gapiii
  • gap1ip4bp
  • LOC100222817
  • GAP1IP4BP
  • GAPIII
  • AI326412
  • C86362
  • E130011G04
  • scat
  • R-ras gap
Epitope
AA 725-834
28
17
13
9
6
5
3
2
2
1
1
1
1
1
1
1
Reactivity
Human
78
27
27
3
1
1
1
1
1
1
Host
Mouse
57
15
7
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
49
45
11
4
2
1
1
Supplier
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Immunogen RASA3 (AAH47242, 725 a.a. ~ 834 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1F11
Isotype IgG2a kappa
Specificity RASA3 (AAH47242, 725 a.a. ~ 834 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name RASA3 (RASA3 Antibody Abstract)
Background The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.
Synonyms: GAP1IP4BP, GAPIII, MGC46517, MGC47588 RAS p21 protein activator 3
Molecular Weight 95699 DA
Gene ID 22821
Research Area Cell Structure, Cell Cycle
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.

Restrictions For Research Use only
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-RAS P21 Protein Activator 3 (RASA3) (AA 725-834) antibody (ABIN395074) Detection limit for recombinant GST tagged RASA3 is approximately 0.3 ng/mL as a capt...
Background publications Kupzig, Bouyoucef-Cherchalli, Yarwood et al.: "The ability of GAP1IP4BP to function as a Rap1 GTPase-activating protein (GAP) requires its Ras GAP-related domain and an arginine finger rather than an asparagine thumb." in: Molecular and cellular biology, Vol. 29, Issue 14, pp. 3929-40, 2009 (PubMed).

Rush, Moritz, Lee et al.: "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." in: Nature biotechnology, Vol. 23, Issue 1, pp. 94-101, 2005 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Walker, Kupzig, Lockyer et al.: "Analyzing the role of the putative inositol 1,3,4,5-tetrakisphosphate receptor GAP1IP4BP in intracellular Ca2+ homeostasis." in: The Journal of biological chemistry, Vol. 277, Issue 50, pp. 48779-85, 2002 (PubMed).