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s100a4 antibody (S100 Calcium Binding Protein A4) (AA 1-102)

Details for Product anti-S100A4 Antibody No. ABIN395081, Supplier: Log in to see
Antigen
  • S100A4
  • 18A2
  • 42A
  • CAPL
  • FSP1
  • MTS1
  • P9KA
  • PEL98
  • 42a
  • Capl
  • FSp1
  • Mts1
  • PeL98
  • metastasin
  • pk9a
  • P9ka
  • RNP9KA
Epitope
AA 1-102
19
18
16
13
10
9
5
5
1
1
1
Reactivity
Human
104
57
32
11
9
4
4
1
Host
Mouse
101
19
12
2
Clonality (Clone)
Monoclonal ()
Conjugate
This s100a4 antibody is un-conjugated
12
9
6
3
3
3
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
74
67
45
34
11
4
4
4
3
2
Supplier
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Immunogen S100A4 (AAH16300, 1 a.a. ~ 102 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1F12-1G7
Isotype IgG1 kappa
Specificity S100A4 (AAH16300, 1 a.a. ~ 102 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name S100A4 (S100A4 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 11729 DA
Gene ID 12406
Research Area Cancer, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-s100a4 antibody (S100 Calcium Binding Protein A4) (AA 1-102) (ABIN395081) Immunofluorescence of monoclonal antibody to S100A4 on HeLa cell (antibody concentrat...
Immunohistochemistry (IHC) image for anti-s100a4 antibody (S100 Calcium Binding Protein A4) (AA 1-102) (ABIN395081) anti-S100 Calcium Binding Protein A4 (S100A4) (AA 1-102) antibody (Image 2)
Background publications van Dieck, Lum, Teufel et al.: "S100 proteins interact with the N-terminal domain of MDM2." in: FEBS letters, Vol. 584, Issue 15, pp. 3269-74, 2010 (PubMed).

Mencía, Selga, Rico et al.: "Overexpression of S100A4 in human cancer cell lines resistant to methotrexate." in: BMC cancer, Vol. 10, pp. 250, 2010 (PubMed).

Cunningham, Docherty, Burke et al.: "S100A4 expression is increased in stricture fibroblasts from patients with fibrostenosing Crohn's disease and promotes intestinal fibroblast migration." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 299, Issue 2, pp. G457-66, 2010 (PubMed).

Zhang, Fu, Chen et al.: "Subcellular distribution of S100A4 and its transcriptional regulation under hypoxic conditions in gastric cancer cell line BGC823." in: Cancer science, Vol. 101, Issue 5, pp. 1141-6, 2010 (PubMed).

Roberts, Kawut, Krowka et al.: "Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease." in: Gastroenterology, Vol. 139, Issue 1, pp. 130-9.e24, 2010 (PubMed).