Glucagon-Like Peptide 2 Receptor (GLP2R) (AA 69-179) antibody

Details for Product No. ABIN395085, Supplier: Log in to see
Antigen
  • GLP1
  • GLP2
  • GRPP
  • 9530092J08Rik
  • GLP-2
  • glucagon-like peptide 2 receptor
  • glucagon
  • GLP2R
  • LOC100338519
  • GCG
  • Glp2r
Alternatives
anti-Human Glucagon-Like Peptide 2 Receptor antibody for Dot Blot
Epitope
AA 69-179
15
13
13
11
10
8
4
4
2
2
1
1
Reactivity
Human
103
8
6
4
Host
Mouse
81
23
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
4
3
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
53
30
24
19
13
12
9
5
4
2
2
1
Options
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Immunogen GLP2R (NP_004237, 69 a.a. ~ 179 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1F2
Isotype IgG2b kappa
Specificity GLP2R (NP_004237, 69 a.a. ~ 179 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GLP2R (GLP2R Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 63001 DA
Gene ID 12406
NCBI Accession NP_004237
Research Area Cell Cycle, Cell Structure
Pathways Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Feeding Behaviour
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R).

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Glucagon-Like Peptide 2 Receptor (GLP2R) (AA 69-179) antibody (ABIN395085) Detection limit for recombinant GST tagged GLP2R is approximately 10 ng/mL as a captu...
Background publications Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Pinheiro, Bulik, Thornton, Sullivan, Root, Bloss, Berrettini, Schork, Kaye, Bergen, Magistretti, Brandt, Crawford, Crow, Fichter, Goldman, Halmi, Johnson, Kaplan, Keel, Klump, La Via, Mitchell, Strober, Rotondo, Treasure, Woodside: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

Rose, Behm, Drgon, Johnson, Uhl: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Festen, Stokkers, van Diemen, van Bodegraven, Boezen, Crusius, Hommes, van der Woude, van der Woude, Balschun, Verspaget, Schreiber, de Jong, Franke, Dijkstra, Wijmenga, Weersma: "Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk." in: The American journal of gastroenterology, Vol. 105, Issue 2, pp. 395-402, 2010 (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).