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Hemochromatosis (HFE) (AA 115-206) antibody

Details for Product No. ABIN395159, Supplier: Log in to see
Antigen
  • HFE1
  • HH
  • HLA-H
  • MVCD7
  • TFQTL2
  • MR2
Epitope
AA 115-206
6
5
4
3
2
2
2
1
1
1
1
1
1
Reactivity
Human
60
20
16
1
Host
Mouse
50
13
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
48
21
12
12
11
5
4
4
1
1
Supplier
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Immunogen HFE (NP_000401, 115 a.a. ~ 206 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1G12
Isotype IgG1 kappa
Specificity HFE (NP_000401, 115 a.a. ~ 206 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HFE (HFE Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 40108 DA
Gene ID 12406
NCBI Accession NP_000401
Research Area Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Hemochromatosis (HFE) (AA 115-206) antibody (ABIN395159) Immunofluorescence of monoclonal antibody to HFE on HeLa cell (antibody concentration...
Immunohistochemistry (IHC) image for anti-Hemochromatosis (HFE) (AA 115-206) antibody (ABIN395159) anti-Hemochromatosis (HFE) (AA 115-206) antibody (Image 2)
Background publications Lehmann, Schuur, Warden et al.: "Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project." in: Neurobiology of aging, Vol. 33, Issue 1, pp. 202.e1-13, 2011 (PubMed).

Phatak, Brissot, Wurster et al.: "A phase 1/2, dose-escalation trial of deferasirox for the treatment of iron overload in HFE-related hereditary hemochromatosis." in: Hepatology (Baltimore, Md.), Vol. 52, Issue 5, pp. 1671-779, 2010 (PubMed).

Schiepers, van Boxtel, de Groot et al.: "Serum iron parameters, HFE C282Y genotype, and cognitive performance in older adults: results from the FACIT study." in: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 65, Issue 12, pp. 1312-21, 2010 (PubMed).

Neghina, Anghel: "Hemochromatosis genotypes and risk of iron overload--a meta-analysis." in: Annals of epidemiology, Vol. 21, Issue 1, pp. 1-14, 2010 (PubMed).

Valenti, Canavesi, Galmozzi et al.: "Beta-globin mutations are associated with parenchymal siderosis and fibrosis in patients with non-alcoholic fatty liver disease." in: Journal of hepatology, Vol. 53, Issue 5, pp. 927-33, 2010 (PubMed).