Angiotensin II Receptor-Associated Protein (AGTRAP) (AA 108-160) antibody

Details for Product No. ABIN395167, Supplier: Log in to see
Antigen
  • AGTRAP
  • DKFZp469M235
  • LOC100223570
  • ATRAP
  • 3300002E14Rik
  • AT1R
  • Atrap
  • D4Wsu124e
  • angiotensin II receptor-associated protein
  • angiotensin II, type I receptor-associated protein
  • AGTRAP
  • LOC100223570
  • Agtrap
Epitope
AA 108-160
13
10
9
8
3
2
2
2
1
Reactivity
Human
47
7
7
Host
Mouse
38
9
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Western Blotting (WB)
32
30
12
5
3
1
1
1
1
1
Options
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Immunogen AGTRAP (NP_065083, 108 a.a. ~ 160 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1G2
Isotype IgG1 kappa
Specificity AGTRAP (NP_065083, 108 a.a. ~ 160 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name AGTRAP (AGTRAP Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 17419 DA
Gene ID 12406
NCBI Accession NP_065083
Research Area Cell Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Angiotensin II Receptor-Associated Protein (AGTRAP) (AA 108-160) antibody (ABIN395167) Western Blot analysis of AGTRAP expression in transfected 293T cell line by AGTRAP mo...
Immunohistochemistry (IHC) image for anti-Angiotensin II Receptor-Associated Protein (AGTRAP) (AA 108-160) antibody (ABIN395167) anti-Angiotensin II Receptor-Associated Protein (AGTRAP) (AA 108-160) antibody (Image 2)
Background publications Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Godin, Ferreira, Dale, Gros, Cregan, Ferguson: "The small GTPase Ral couples the angiotensin II type 1 receptor to the activation of phospholipase C-delta 1." in: Molecular pharmacology, Vol. 77, Issue 3, pp. 388-95, 2010 (PubMed).

Newton-Cheh, Johnson, Gateva, Tobin, Bochud, Coin, Najjar, Zhao, Heath, Eyheramendy, Papadakis, Voight, Scott, Zhang, Farrall, Tanaka, Wallace, Chambers, Khaw, Nilsson, van der Harst, Polidoro, Grobbee, Onland-Moret, Bots, Wain, Elliott, Teumer, Luan, Luc: "Genome-wide association study identifies eight loci associated with blood pressure." in: Nature genetics, Vol. 41, Issue 6, pp. 666-76, 2010 (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Rabbitts, Strom, Sawyer, Curry, Dietz, Roberts, Kingsley-Berg, Charkoudian: "Influence of endogenous angiotensin II on control of sympathetic nerve activity in human dehydration." in: The Journal of physiology, Vol. 587, Issue Pt 22, pp. 5441-9, 2009 (PubMed).