Kynureninase (L-Kynurenine Hydrolase) (KYNU) antibody

Details for Product No. ABIN395171
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Synonyms 4432411A05Rik, BA2753
(20), (4), (4), (2)
(16), (6)
Clonality (Clone)
Monoclonal ()
ELISA, Western Blotting (WB)
(21), (7), (5), (5), (3), (2), (2), (2), (1)
Pubmed 5 references available
Catalog no. ABIN395171
Quantity 0.1 mg
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Immunogen KYNU (NP_003928, 2 a.a. ~ 109 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1G2
Isotype IgG2a lambda
Specificity KYNU (NP_003928, 2 a.a. ~ 109 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name KYNU
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 52352 DA
Gene ID 12406
UniProt NP_003928
Research Area Metabolism, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Two transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Kynureninase (L-Kynurenine Hydrolase) (KYNU) antibody Detection limit for recombinant GST tagged KYNU is approximately 0.1 ng/mL as a capture antibody.
Background publications Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Magni, Amici, Emanuelli et al.: "Enzymology of NAD+ homeostasis in man." in: Cellular and molecular life sciences : CMLS, Vol. 61, Issue 1, pp. 19-34, 2004 (PubMed).

Zhang, Zhang, He et al.: "[A polymorphism of kynureninase gene in a hypertensive candidate chromosomal region is associated with essential hypertension]." in: Zhonghua xin xue guan bing za zhi, Vol. 33, Issue 7, pp. 588-91, 2005 (PubMed).

Christensen, Duno, Lund et al.: "Xanthurenic aciduria due to a mutation in KYNU encoding kynureninase." in: Journal of inherited metabolic disease, Vol. 30, Issue 2, pp. 248-55, 2007 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Hosts (16), (6)
Reactivities (20), (4), (4), (2)
Applications (21), (7), (5), (5), (3), (2), (2), (2), (1)
Epitopes (3), (2), (2), (2), (1), (1), (1), (1)
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